Bisisopropyl peroxydicarbonate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1958

Report date:

1958

Materials and methods

Principles of method if other than guideline:

Acute toxic method

GLP compliance:

no

Test type:

traditional method

Test material

Test material information

Constituent 1

Reference substance name:

Bisisopropyl peroxydicarbonate

EC Number:

203-317-4

EC Name:

Bisisopropyl peroxydicarbonate

Cas Number:

105-64-6

Molecular formula:

C8H14O6

IUPAC Name:

2-[({[(propan-2-yloxy)carbonyl]peroxy}carbonyl)oxy]propane

Details on test material:

SMILES (used for QSAR prediction): C(=O)(OC(C)C)OOC(=O)OC(C)C
Molecular Formula: C8 H14 O6
Molecular weight (g/mole): 206.2

Specific details on test material used for the study:

Isopropyl Peroxycarbonate on June 3, 1957 from Mr. Lynn King, Columbia-Southern Chemical Corp., Barberton, Ohio.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 200-250 grams

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

clean air

Details on inhalation exposure:

A group of ten animals was placed in a closed but not sealed stainless steel chamber measuring 12 in. x 18 in. x 2.4 in. The rats were placed on a wire mesh false bottom about 2. in. above the chamber floor. A stream of cool water upon the outside of the chamber served to cool it and to dissipate the body heat of the animals. The solid test material was added slowly over a period of eight hours. A total of 48 grams of the solid sample waa added over the test period through a loosely covered circular hole one inch in diameter in the side of the chamber onto the chamber floor.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

Saturated vapor concentration of bisisopropyl peroxydicarbonate and/or its degradation products

No. of animals per sex per dose:

10

Details on study design:

Immediately after exposure and again one week later five animals were sacrificed. Their lungs were removed, fixed and submitted for histological e:xamination.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LC0

Exp. duration:

8 h

Remarks on result:

other: Saturated vapor concentration of bisisopropyl peroxydicarbonate and/or its degradation products

Remarks:

No symptoms of abnormality or distress

Mortality:

None

Clinical signs:

other: No symptoms of abnormality or distress attributable to the sample were noted during the exposure period. Similarly no effects were observed in those animals maintained for a one week period after treatment on a normal laboratory routine.

Gross pathology:

The histopathological report of the examination of the lungs of these animals revealed no significant effects due to the treatment.

Applicant's summary and conclusion

Executive summary:

No symptoms of abnormality and histopathological changes in lungs were noted during a 8-hour inhalation exposure to saturated vapor concentration of bisisopropyl peroxydicarbonate and/or its degradation products.