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EC number: 290-611-0 | CAS number: 90194-04-0
The test substance, 1,3-Benzenedimethanamine, reaction products with glycidyl tolyl ether, was evaluated for its clastogenic activity and/or disruption of the mitotic apparatus by detecting micronuclei in polychromatic erythrocyte (PCE) cells in rat bone marrow. Corn Oil was selected as the vehicle. Test and/or control substance formulations were administered once per day on two consecutive days at a dose volume of 10 mL/kg by oral gavage.
In the dose range-finding assay (DRF), the maximum dose tested was 2000 mg/kg/day. The dose levels tested were 500, 1000, and 2000 mg/kg/day in 3 of animals/sex. Based upon the results, the high dose for the definitive assay was 500 mg/kg/day, which was estimated to be the maximum tolerated dose (MTD)
The definitive assay dose levels tested were 125, 250, and 500 mg/kg/day.
No statistically significant increase in the incidence of MnPCEs in the test substance treated groups was observed relative to the vehicle control groups. The positive control induced a statistically significant increase in the incidence of MnPCEs. The number of MnPCEs in the vehicle control groups did not exceed the historical control range.
Under the conditions of this study, the administration of 1,3-Benzenedimethanamine, reaction products with glycidyl tolyl ether at doses up to and including a dose of 125, 250, and 500 mg/kg/day was concluded to be negative in the Micronucleus assay.
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