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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
13 October 2017 to 16 October 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: Knudsen cell
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0 Pa
Key result
Test no.:
#3
Temp.:
50 °C
Vapour pressure:
0.001 Pa

The vapour pressure could be measured in the temperature range of 50 to 90 °C. The measured vapour pressures at the corresponding temperatures are listed in Table 1. After the measurement a mass loss of approx. 6 % (w/w) was determined.

 

Table 1: Measured vapour pressures and corresponding temperatures

Temperature (°C)

Vapour Pressure (hPa)

50

8.3 x10^-6*

60

1.3 x10^-5

70

2.5 x10^-5

80

5.5 x10^-5

90

9.9 x10^-5

*= Below the recommended range for this method.

 

The values for 20, 25 and 50 °C are calculated, using the Antoine constants A, B and C as shown in Table 2. The vapour pressure measured at 50 °C was not included in the linear regression because it is below the recommended range for this method.

 

Table 2: Antoine parameters and extrapolated vapour pressures

Temperature (°C)

Vapour Pressure (hPa)

log (p/hPa) = A + B/(C+ T [°C])

20

4.4 x10^-7

A = 5.87228

25

7.0 x10^-7

B = -3585.42

50

6.0 x10^-6

C = 273.15

 

Table 3: Final Results

Temperature (°C)

Vapour Pressure (hPa)

Vapour Pressure (Pa)

20

4.4 x10^-7

4.4 x10^-5

25

7.0 x10^-7

7.0 x10^-5

50

6.0 x10^-6

6.0 x10^-4

Conclusions:
Under the conditions of this study the vapour pressure of the test material was 0.000044, 0.00007 and 0.0006 Pa at 20, 25 and 50 °C, respectively.
Executive summary:

The vapour pressure of the test material was investigated in accordance with the standardised guidelines OECD 104 and EU Method A.4., under GLP conditions using the Knudsen cell effusion method.

Under the conditions of this study the vapour pressure of the test material was 0.000044, 0.00007 and 0.0006 Pa at 20, 25 and 50 °C, respectively.

Description of key information

Under the conditions of this study the vapour pressure of the test material was 0.000044, 0.00007 and 0.0006 Pa at 20, 25 and 50 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure of the test material was investigated in accordance with the standardised guidelines OECD 104 and EU Method A.4., under GLP conditions using the Knudsen cell effusion method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

Under the conditions of this study the vapour pressure of the test material was 0.000044, 0.00007 and 0.0006 Pa at 20, 25 and 50 °C, respectively.