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EC number: 212-990-3
CAS number: 903-19-5
Clinical signs: No signs of ill
health or toxicity were recorded.
Bodyweight: Increases were recorded
for all guinea-pigs over the period of the study.
- Intradermal injections: necrosis was
recorded at all sites receiving Freund's complete adjuvant, in test and
- Slight irritation was seen in test
animals' sites receiving tetramethylbutylhydrochinon 7.5% w/v in 5%
acetone in coconut oil, and slight irritation was seen in control
animals' sites receiving 5% acetone in coconut oil.
- Topical application: Slight erythema was
seen in test animals' sites following application with
tetramethylbutylhydrochinon 60% w/v in acetone, and slight erythema was
seen in control animals' sites following application with acetone.
-Challenge application: No dermal reactions
were seen in any test or control animals following the challenge topical
application with tetramethylbutylhydrochinon 60% w/v or 30% w/v, in
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