Alcohols, C18-unsatd and ethoxylated C18-unsatd., phosphates (5 moles ethoxylation)

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From November 06, 2017 to February 01, 2018

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

non-GLP

Qualifier:

according to guideline

Guideline:

other: OECD Guideline 105: Water solubility

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

other: EU Method A.6 Water Solubility

Deviations:

not specified

GLP compliance:

no

Remarks:

The study was conducted in a facility which operates in accordance with Good Laboratory Practice principles; however no claim of GLP compliance was intended nor is made for this study

Key result

Medium:

n-octanol

Solubility:

ca. 250 g/L

Temp.:

20 °C

Test substance stable:

not determined

Results

Preliminary Test

The recorded observations for the contents of the cylinder after each addition of n-octanol are shown in the following table:

Table 1

Total Volume of n-Octanol Added (mL)	Saturation Concentration (g/L)	Observations
0.5	232	Pale yellow/straw colored solution, no excess test substance present

The solubility was estimated to begreater than 200 g/L and definitive testing was continued using the MT 181 method.

 

Definitive Test

The recorded observations for the contents of the cylinder after each addition of n-octanol are shown in the following tables:

 

Table 2 Sample 1

Total Volume of n-Octanol Added (mL)	Saturation Concentration (g/L)	Observations
2	252	Transparent, pale yellow colored solution, no excess test substance present

 

Table 3 Sample 2

Total Volume of n-Octanol Added (mL)	Saturation Concentration (g/L)	Observations
2	254	Transparent, pale yellow colored solution, no excess test substance present

The solubility was estimated to be greater than 250 g/L.

 

Discussion

This visual assessment result has been obtained considering the test substance as a whole. As the test substance is a complex mixture, the solubility of the individual constituents may differ.

 

Conclusion

The octanol solubility of the test substance has been determined to be greater than 250 g/L of solution at 20.0 ± 0.5 °C.

Conclusions:

Under the study conditions, the n-octanol solubility of the test substance was determined to be 250 g/L of solution at 20.0 ± 0.5°C.

Executive summary:

A study was conducted to determine the n-octanol solubility of the test substance using an adapted flask method, according to OECD Guideline 105 and EU Method A.6. Under the study conditions, the n-octanol solubility of the test substance was determined to be 250 g/L of solution at 20.0 ± 0.5°C (Envigo, 2018).

Description of key information

The n-octanol solubility of the test substance was determined using an adapted flask method, according to OECD Guideline 105 and EU Method A.6 (Envigo, 2018).

Key value for chemical safety assessment

At the temperature of:

20 °C

Solubility in organic solvents at 20°C:

250 g/L