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EC number: 262-309-9 | CAS number: 60580-61-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1987-02-24
- Deviations:
- yes
- Remarks:
- body weight was not recorded during the observation period
- GLP compliance:
- no
- Remarks:
- not mandatory at the time of study conduct
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Test material form:
- liquid - solid: mixture of
- Details on test material:
- 46.4% aqueous suspension of zinc 5-nitroisophthalate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: WIGA, Sulzfeld
- Weight (mean): males: 235 g; females: 175 g
- Fasting period before study: ca. 16 hours before administration
- Diet (ad libitum): Altromin R 1324 (ALTROMIN GmbH, LAge/Lippe)
- Water (ad libitum)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- 0.5 aqueous solution of carboxymethyl cellulose
DOSAGE PREPARATION:
The product was prepared as a 46.4 % suspension in the vehicle. - Doses:
- 10000 mg/kg bw
- No. of animals per sex per dose:
- 10 males / 10 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Examinations performed:
clinical signs
mortality: 1, 24 und 48 house as well as 7 and 14 days after adminsitration
- Necropsy of survivors performed: yes - Statistics:
- not applicable
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 640 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Calculated LD50 for Sicorin RZ = 4640 mg/kg bw
- Mortality:
- No mortality occurred.
- Clinical signs:
- No symptom of poisoning was observed.
- Body weight:
- not specified
- Gross pathology:
- No findings were made during the autopsy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 (rats, combined sexes) > 10000 mg/kg bw (calculated for Sicorin RZ = 4640 mg/kg bw)
According to the Regulation (EC) No 1272/2008 and subsequent adaptations, the substance is not acutely toxic via the oral route.
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