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EC number: 947-917-0 | CAS number: -
Table A6.6.2-1:Metaphase chromosome analysis of human lymphocytes after exposure to the test item or mitomycin C in the absence of S9-mix.
An inhibition of growth of 50 % was judged to lie at a concentration of 27.4 µg/mL of the test item
No. of cells analysed
No. of cells with aberrations
% cells with aberrations
**) p<0.01 Fisher’s exact probability test (two sided)
***) p<0.001 Fisher’s exact probability test (two-sided)
1) percentage of metaphases determined in 1000 nuclei (mean value of duplicate cultures)
Table A6.6.2-2:Metaphase chromosome analysis of human lymphocytes after exposure to the test item or cyclophosphamide in the presence of S9-mix.
The in vitro genotoxicity of DOPA-Glycinate (20% a.i.) was tested in human lymphocytes. The study was carried out according to OECD guideline 473 (1983). No relevant deviations from the prescribed test guideline were reported.The test was performed at concentrations of 0, 1.11, 3.33, 10.0 and 30.0 µg/mL in the presence and absence of metabolic activation (S9 mix). A reduction of the mitotic index to about 60 % or 54 % of the vehicle control without or with S9 mix, respectively, was observed at the highest test concentration (30 µg/mL) indicating cytotoxicity. The positive controls resulted in the appropriate responses.
The test item did not induce structural chromosome damage in cultured human lymphocytes either in the presence or in the absence of S9-mix.
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