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EC number: 947-917-0 | CAS number: -
Score at time point / Reversibility
Max. score: 4
Max. score: 2
Max. score: 3
Average 24h, 48h, 72h
Eyes rinsed after 30 s
In a primary eye irritation study according to EPA OPP 81-4, 0.1 mL of Reaction product of lauryl-PDA/lauryl-DETA with chloroacetic acid (22.5% a.i.) was instilled into the conjunctival sac one eye of 9 New Zealand White rabbits. In 6 animals, the eyes were not rinsed after application, in 3 animals they eyes were rinsed for one minute with saline 30 seconds after application of the test item. Animals were then observed for 21 d.
The test item produced severe redness and chemosis in 6 of 6 animals in the no rinse group and 3 of 3 animals in the rinse group. The test article produced severe irreversible corneal opacity and iritis in all test animals in both the no rinse and rinse groups. All animals in both test groups developed severe pannus by day 21. Rinsing did not prevent ocular damage.
In this study, Reaction product of lauryl-PDA/lauryl-DETA with chloroacetic acid (22.5% a.i.) caused irreversible damage to the eye.
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