Registration Dossier

Physical & Chemical properties

Water solubility

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Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-03-20
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
column elution method
Key result
Water solubility:
>= 0.024 - <= 70 µg/L
Conc. based on:
test mat.
Loading of aqueous phase:
500 µg/L
Incubation duration:
>= 1 - <= 17 d
Temp.:
20 °C
pH:
> 6.1 - < 6.3
Conclusions:
The water solubility of the test item was determined to be in range of 0.024 µg/L (based on Titanium) and 70 µg/L (based on Lanthanum) at 20 °C.

Description of key information

The water solubility of the test item was determined to be in range of 0.024 µg/L (based on Titanium) and 70 µg/L (based on Lanthanum) at 20 °C.

Key value for chemical safety assessment

Water solubility:
0.024 µg/L
at the temperature of:
20 °C

Additional information

The water solubility will be determined according to OECD 105 using the column elution method with ICP analysis. The water solubility of the test item was estimated to be in range of 0.024 µg/L (based on Titanium oxide) and 70 µg/L (based on Lanthanum oxide) at 20 °C. These data are based on the published data on titanium dioxide and lanthanum oxide. The study was initiated before 31 March 2018 but was not completed by the CRO in due time to complete the registration dossier. The study record will be updated as soon as the results will become available.