α-chloro-2-fluorotoluene

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

November 21, 2019 - March 18, 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Test material

Test material information

Constituent 1

Reference substance name:

Reference substance 001

Cas Number:

345-35-7

Test material form:

liquid

Results and discussion

Melting / freezing point

Key result

Melting / freezing pt.:

-18.5 °C

Any other information on results incl. tables

Within two DSC measurements the test item was cooled down to -80 °C with a cooling rate of 1 K/min, -80 °C were kept for 60 min and afterwards the test item was heated up to 25 °C with a heating rate of 10 K/min. During heating up the measurements showed an endothermal effect (melting) in the temperature range of -25 °C to -10 °C. The onset temperature (see Table 1) was derived from the intersection of the tangent line with the highest slope of the endothermal peak with the baseline.

The results of the DSC measurements in aluminium crucibles are summarized in Table 1.

Table 1: Melting point (DSC measurements in open aluminium crucibles)

Ident No.	Test item / mg	Starting temperature / °C	Final test temperature / °C	Temperature range (endo-thermal) / °C	Onset (melting) / °C	Crucible	Observations after the measurement
38915	15.24	-80	25	(-25) – (-10)	-23.46	Aluminium with a hole	Test item was unchanged
38920	9.04	-80	25	(-25) – (-15)	-23.27	Aluminium with a hole	Test item was unchanged

Graphical presentations of the DSC runs are shown on page 8 (Figure 1).

As in the safety data sheet (SDS-Number 122000001459, 2-Fluorbenzylchlorid; version 8.0) of the test item chapter 10.3 stated, that the test item reacts with many metals two additional DSC measurements were performed in open glass crucibles as follows: The test item was cooled down to -80 °C with a cooling rate of 1 K/min, -80 °C were kept for 60 min and afterwards the test item was heated up to 300 °C with a heating rate of 10 K/min. During heating up, the measurements showed an endothermal effect (melting) in the temperature range of -25 °C to 0 °C. The onset temperature (see Table 2) was derived from the intersection of the tangent line with the highest slope of the endothermal peak with the baseline.

The results of the DSC measurements in open glass crucibles are summarized in Table 2.

 

Table 2: Melting point (DSC measurements in open glass crucibles)

Ident No.	Test item / mg	Starting temperature / °C	Final test temperature / °C	Temperature range (endo-thermal) / °C	Onset (melting) / °C	Crucible	Observations after the measurement
39070	13.21	-80	300	-25 – 0	-18.63	Glass (open)	Empty crucible
39072	13.51	-80	300	-25 – 0	-18.44	Glass (open)	Empty crucible

Graphical presentations of the DSC runs are shown on page 9 (Figure 2).

As it was assumed that the test item reacted with the aluminum crucible, only the results from the DSC measurements of the test item in glass crucibles were used for the determination of the melting point. The test item had a mean melting point of -18.5 °C.

Applicant's summary and conclusion

Executive summary:

The test item had a mean melting point of -18.5 °C.