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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

WoE approach based on Klimish 4 _1 page study summary :

- Acute Oral toxicity in rats on Rhodial abstract_ dated on 1977_LD50 (Oral) >5000 mg/Kg bw

- Acute Dermal toxicity in rabbits on Rhodial abstract_ dated on 1977_LD50 (dermal) >5000 mg/Kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1977
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract
Remarks:
1 page summary
Qualifier:
according to guideline
Guideline:
other: no guideline specified on the 1 page study summary
GLP compliance:
no
Remarks:
Conducted prior to the GLP guidelines
Limit test:
yes
Specific details on test material used for the study:
Sample marking: 77-413, Rhodial
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
5'000 mg/Kg BW
No. of animals per sex per dose:
1 dose per animals
Control animals:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No death occurred
Other findings:
Tox signs: Slight lethargy , chromorhinorrhea
Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 of SILVIAL in rat has been determined to be above 5'000 mg/Kg bw. Hence the GHS criteria are not met for classification.
Executive summary:

The LD50 of SILVIAL in rat has been determined to be above 5'000 mg/Kg bw. Hence the GHS criteria are not met for classification.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1977
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract
Remarks:
1 page study summary
Qualifier:
according to guideline
Guideline:
other: no guideline specified on the 1 page study summary
GLP compliance:
no
Remarks:
Conducted prior to the GLP guidelines
Limit test:
yes
Specific details on test material used for the study:
Sample marking: 77-413, Rhodial
Species:
rabbit
Strain:
not specified
Sex:
not specified
Type of coverage:
not specified
Vehicle:
not specified
Doses:
5'000 mg/Kg BW
No. of animals per sex per dose:
1 dose per animals
Control animals:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
1 death occurred on day 1
Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 of Silvial in rabbits has been determined to be above 5'000 mg/Kg bw. Hence the GHS criteria are not met for classification.
Executive summary:

The LD50 of Silvial in rabbits has been determined to be above 5'000 mg/Kg bw. Hence the GHS criteria are not met for classification.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw

Additional information

Justification for classification or non-classification

The LD50 (oral and dermal) of SILVIAL in rats and rabbits have been determined to be both above 5'000 mg/Kg bw. Hence the GHS criteria are not met for classification.