3,4,5-trihydroxybenzoic acid

Appearance / physical state / colour

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

appearance / physical state / colour

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Principles of method if other than guideline:

Observation

GLP compliance:

no

Specific details on test material used for the study:

Gallic acid was obtained from Dainippon Pharmaceutical Co. Ltd (Osaka, Japan), as a yellowish-white crystalline powder with a purity over 98%. The preparation had little odor, and was astringent and somewhat acid in taste.

Physical state at 20°C and 1013 hPa:

solid

Remarks:

yellowish-white crystalline powder

Conclusions:

Gallic acid with a purity of 98% is described as a yellowish-white crystalline powder in 90-day subchronic toxicity on rats.

Executive summary:

Gallic acid with a purity of 98% is described as a yellowish-white crystalline powder in 90-day subchronic toxicity on rats.

Reference 2

Endpoint:

appearance / physical state / colour

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Principles of method if other than guideline:

Observation

GLP compliance:

no

Specific details on test material used for the study:

3,4,5-trihydroxybenzoic acid (gallic acid hydrate; CAS# 149-91-7; Lot# CBEJB; mass fraction purity ≥ 0.97 powder) was obtained from VWR (Batavia, IL, USA)

Physical state at 20°C and 1013 hPa:

solid

Remarks:

powder

Conclusions:

Gallic acid with a purity ≥ 97% is described as a powder in water solubility test.

Executive summary:

Gallic acid with a purity ? 97% is described as a powder in water solubility test.

Reference 3

Endpoint:

appearance / physical state / colour

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Principles of method if other than guideline:

observation

GLP compliance:

no

Specific details on test material used for the study:

Gallic acid (98 % purity) was obtained as dry powder from Acros Organics (no. 410860010).

Physical state at 20°C and 1013 hPa:

solid

Remarks:

dry powder

Conclusions:

Gallic acid witha purity of 98% is described as a dry powder in fish acute toxicity test.

Executive summary:

Gallic acid witha purity of 98% is described as a dry powder in fish acute toxicity test.

Reference 4

Endpoint:

appearance / physical state / colour

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: no guideline applies to this simple observation endpoint

Qualifier:

no guideline required

Principles of method if other than guideline:

visual inspection

GLP compliance:

no

Physical state at 20°C and 1013 hPa:

solid

Key result

Form:

solid

Colour:

white or yellowish-white or fawn-colored, crystalline needles or prisms

Odour:

odourless

Substance type:

organic

Conclusions:

The test item is a white or yellowish-white or fawn-colored solid, in the form of crystalline needles or prisms, odorless.

Description of key information

The weight of evidence approach may apply as 3 independent sources of information are availble.

The state of gallic acid (with purity between 97 and 98%) is provided as information in material and methods of three publications:

-Yellowish-white crystalline powder in 90 -day subchronic toxicity test on rats (Niho et al., 2001)

- Dry powder in fish acute toxicity test (Techer et al., 2015a)

- Powder in water solubility test (Srinivas et al., 2010)

This is supported by visual inspection of the test item that is is a white or yellowish-white or fawn-colored solid, in the form of crystalline needles or prisms, odorless.

Key value for chemical safety assessment

Physical state at 20°C and 1013 hPa:

solid