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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation / corrosion, other
Remarks:
Human volunteer study
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1974
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
- Principle of test: Skin irritation study in human volunteers as a 'pre-test' for a skin sensitization study.
- Short description of test conditions: Five subjects were exposed to the test item for 48 hours.
- Parameters analysed / observed: No details reported.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
trans-hex-2-enal
EC Number:
229-778-1
EC Name:
trans-hex-2-enal
Cas Number:
6728-26-3
Molecular formula:
C6H10O
IUPAC Name:
trans-hex-2-enal
Test material form:
liquid
Specific details on test material used for the study:
No details reported.

Test animals

Species:
other: Human volunteers (male)
Strain:
other: Not applicable
Details on test animals or test system and environmental conditions:
No details on the test subjects were reported.

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
no
Amount / concentration applied:
No details reported.
Duration of treatment / exposure:
48 hours
Observation period:
No details reported.
Number of animals:
Five healthy adult male volunteers.
Details on study design:
No details reported.

Results and discussion

In vivo

Results
Irritation parameter:
other: Not specified
Basis:
other: Not specified
Time point:
other: Not specified
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No subject had any irritation from the test item. No further details reported.
Other effects:
No details reported.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
A patch of the test item was applied to the normal sites on the backs of five human volunteers for 48 hours under occlusion. No subject had any irritation from the test item.
Executive summary:

A patch of the test item was applied to the normal sites on the backs of five human volunteers for 48 hours under occlusion. No subject had any irritation from the test item.