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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1971
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Acute and short-term toxicity studies on trans-2-hexenal
Author:
Gaunt IF; Colley J; Wright M; Creasey M; Grasso P; Gangolli SD
Year:
1971
Bibliographic source:
Food and Cosmetics Toxicology (Continued by Food and Chemical Toxicology); 9(6), 775-786

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Oral LD50 test (no further details available).
GLP compliance:
not specified
Test type:
other: Test type not reported
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
trans-hex-2-enal
EC Number:
229-778-1
EC Name:
trans-hex-2-enal
Cas Number:
6728-26-3
Molecular formula:
C6H10O
IUPAC Name:
trans-hex-2-enal
Test material form:
liquid
Specific details on test material used for the study:
No details reported.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No details reported.

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No details reported.
Doses:
No details reported.
No. of animals per sex per dose:
No details reported.
Control animals:
not specified
Details on study design:
No details reported.
Statistics:
No details reported.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
780 mg/kg bw
Based on:
not specified
Mortality:
No details reported.
Clinical signs:
other: No details reported.
Gross pathology:
No details reported.
Other findings:
No details reported.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Oral LD50 values for the test substance were reported to be 780 -1130 mg/kg bw in rats.
Executive summary:

An oral LD50 range of 780-1130 mg/kg bw in rats has been reported. Therefore, the test item is classified as a Category 4 Acute toxicity (H302) according to CLP criteria (EC Regulation 1272/2008).