Registration Dossier
Registration Dossier
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EC number: 229-778-1 | CAS number: 6728-26-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1971
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute and short-term toxicity studies on trans-2-hexenal
- Author:
- Gaunt IF; Colley J; Wright M; Creasey M; Grasso P; Gangolli SD
- Year:
- 1 971
- Bibliographic source:
- Food and Cosmetics Toxicology (Continued by Food and Chemical Toxicology); 9(6), 775-786
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Oral LD50 test (no further details available).
- GLP compliance:
- not specified
- Test type:
- other: Test type not reported
- Limit test:
- no
Test material
- Reference substance name:
- trans-hex-2-enal
- EC Number:
- 229-778-1
- EC Name:
- trans-hex-2-enal
- Cas Number:
- 6728-26-3
- Molecular formula:
- C6H10O
- IUPAC Name:
- trans-hex-2-enal
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- No details reported.
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No details reported.
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No details reported.
- Doses:
- No details reported.
- No. of animals per sex per dose:
- No details reported.
- Control animals:
- not specified
- Details on study design:
- No details reported.
- Statistics:
- No details reported.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 780 mg/kg bw
- Based on:
- not specified
- Mortality:
- No details reported.
- Clinical signs:
- other: No details reported.
- Gross pathology:
- No details reported.
- Other findings:
- No details reported.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Oral LD50 values for the test substance were reported to be 780 -1130 mg/kg bw in rats.
- Executive summary:
An oral LD50 range of 780-1130 mg/kg bw in rats has been reported. Therefore, the test item is classified as a Category 4 Acute toxicity (H302) according to CLP criteria (EC Regulation 1272/2008).
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