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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1971
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Acute and short-term toxicity studies on trans-2-hexenal
Author:
Gaunt IF; Colley J; Wright M; Creasey M; Grasso P; Gangolli SD
Year:
1971
Bibliographic source:
Food and Cosmetics Toxicology (Continued by Food and Chemical Toxicology); 9(6), 775-786

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Oral LD50 test (no further details available).
GLP compliance:
not specified
Test type:
other: Test type not reported
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
trans-hex-2-enal
EC Number:
229-778-1
EC Name:
trans-hex-2-enal
Cas Number:
6728-26-3
Molecular formula:
C6H10O
IUPAC Name:
trans-hex-2-enal
Test material form:
liquid
Specific details on test material used for the study:
No details reported.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No details reported.

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No details reported.
Doses:
No details reported.
No. of animals per sex per dose:
No details reported.
Control animals:
not specified
Details on study design:
No details reported.
Statistics:
No details reported.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
780 mg/kg bw
Based on:
not specified
Mortality:
No details reported.
Clinical signs:
No details reported.
Body weight:
No details reported.
Gross pathology:
No details reported.
Other findings:
No details reported.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Oral LD50 values for the test substance were reported to be 780 -1130 mg/kg bw in rats.
Executive summary:

An oral LD50 range of 780-1130 mg/kg bw in rats has been reported. Therefore, the test item is classified as a Category 4 Acute toxicity (H302) according to CLP criteria (EC Regulation 1272/2008).

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