Trihexyl benzene-1,2,4-tricarboxylate

Acute Toxicity: oral

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Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

2002

Report date:

2002

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Test animals

Species:

rat

Strain:

Crj: CD(SD)

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: 6 weeks
- Weight at study initiation: 149-163 g for male, 126-140 g for female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 40% w/v

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Each rat was weighed immediately prior to treatment, 7 and 14 days after post-treatment observation period. The rats were observed each hour to 6hr, after that, 2 times for one day during this time for signs of toxicity.
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight, organ weights, gross pathology

Statistics:

Not applicable because of no fatality

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

None

Clinical signs:

None

Body weight:

The test substance did not cause any changes in body weight.

Gross pathology:

No macroscopic abnormalities that could be attributed to treatment with the test substance were seen on pathological examination.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The test material was evaluated for acute oral toxicity following OECD guideline 401. The test substance was non-toxic in rats at doses up to 2000 mg/kg bw. GHS criteria for acute oral toxicity classification are not met.