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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Version / remarks:
2004
Deviations:
not specified
GLP compliance:
yes
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Nominal and measured concentrations:
The experimental test was performed with a control series and an additive control series at 17.1 mg/L, 30.9 mg/L, 55.6 mg/L, 100.0 mg/L, and 180.0 mg/L.
Key result
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
>= 180 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
LOEC
Effect conc.:
>= 180 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
>= 180 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Validity criteria fulfilled:
not specified
Conclusions:
The test substance (TOTM) did not induce acute immobilisation of Daphnia magna at nominal concentrations of 17.1 mg/L, 30.9 mg/L, 55.6 mg/L, 100.0 mg/L, and 180.0 mg/L after 48 h of exposure. The 48-h NOEC, 48-h LOEC and 48-hr EC50 were each reported as ≥ 180.0 mg/L.

Description of key information

The test substance (TOTM, an analogue substance through read-across) did not induce acute immobilisation of Daphnia magna at nominal concentrations of 17.1 mg/L, 30.9 mg/L, 55.6 mg/L, 100.0 mg/L, and 180.0 mg/L after 48 h of exposure.  The 48-h NOEC, 48-h LOEC and 48-hr EC50 were each reported as ≥ 180.0 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
180 mg/L

Additional information