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Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is highly insoluble in water, hence indicating that aquatic toxicity is unlikely to occur
Justification for type of information:
According to QSAR estimation methods (using USA EPISUITE modules WATERNT and WSKOW) for the three main components of C.I. Solvent Blue 79B, the water solubility ranged anywhere from 3.52E-09 to 6.7 E-6mg/L.  Using the column elution method, the water solubility of C.I. Solvent Blue 79B was determined to be <0.1 mg/L at 20°C.  

The USA EPISUITE KOWWIN (v.1.69) was also used to predict the Log Kow of the 3 main components, and these ranged from 10.98 to 11.42

Using the ECOSAR program (developed by the US Environmental Protection Agency’s Office of Chemical Safety and Pollution Prevention, v 1.11), the predicted effect levels for acute toxicity to daphnia exceeded the estimated water solubility of each of the chemical structures evaluated. Thus, no acute effects at water saturation were predicted for the test material, and the study was deemed scientifically not necessary.

No acute effects at water saturation were predicted for the test material, therefore acute testing with daphnia is waived since the study is scientifically not necessary.

Description of key information

According to QSAR estimation methods (using USA EPISUITE modules WATERNT and WSKOW) for the three main components of C.I. Solvent Blue 79B, the water solubility ranged anywhere from 3.52E-09 to 6.7 E-6mg/L.  Using the column elution method, the water solubility of C.I. Solvent Blue 79B was determined to be <0.1 mg/L at 20°C.  

The USA EPISUITE KOWWIN (v.1.69) was also used to predict the Log Kow of the 3 main components, and these ranged from 10.98 to 11.42

Using the ECOSAR program (developed by the US Environmental Protection Agency’s Office of Chemical Safety and Pollution Prevention, v 1.11), the predicted effect levels for acute toxicity to daphnia exceeded the estimated water solubility of each of the chemical structures evaluated.  Thus, no acute effects at water saturation were predicted for the test material, and the study was deemed scientifically not necessary.

No acute effects at water saturation were predicted for the test material, therefore acute testing with daphnia is waived since the study is scientifically not necessary.

Key value for chemical safety assessment

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