4-methylcyclohexanone

Melting point / freezing point

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1938

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Remarks:

No details on the method used or experimental setup. Some details on sample purification provided.

Qualifier:

no guideline followed

Principles of method if other than guideline:

no information on the method reported

GLP compliance:

no

Type of method:

other: no information reported

Specific details on test material used for the study:

Commercially available 4-Methylcyclohexanone was purified as follows:
4-Methylcyclohexanone was treated with a freshly prepared oversaturated filtered solution of sodium hydrogene sulfite. After shaking strongly for 3 hours the system was frozen. The next day, the solid parts were dried and washed extensively with cold ether. As soon as dried, the bisulfite derivates were decomposed with sodium carbonate. The 4-methylcyclohexanone released was rectified systematically by powerful Crismer Columns (35 spires) with external heating.

Key result

Melting / freezing pt.:

-40.6 °C

Atm. press.:

ca. 1 atm

The pressure of the determination was assumed by the registrant to be 1 atmosphere.

Conclusions:

The fusion point for 4-Methylcyclohexanone was reported to be -40.6°C.

Executive summary:

The fusion point for 4-Methylcyclohexanone was reported to be -40.6°C.

Reference 2

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1940

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Remarks:

No details on sample purity. No clear details on experimental method or setup for melting/freezing point determination.

Principles of method if other than guideline:

Equipment used was essentially that described by Morgan ans Lowry, J. Phys. Chem., 34,2385 (1930).
Grounded capacity measurements were made with a condenser consisting of 3 parallel plates of gold-plated brass, which was immersed in the liquid.

GLP compliance:

no

Type of method:

other: no detailed information was reported

Specific details on test material used for the study:

4-Methylcyclohexanone supplied by Eastman Kodak Co.

Key result

Melting / freezing pt.:

-41 °C

Atm. press.:

ca. 1 atm

The experimental pressure was assumed by the registrant to be one atmosphere.

Conclusions:

The melting point observed for 4-Methylcyclohexanone was reported as -41°C.

Executive summary:

The melting point observed for 4-Methylcyclohexanone was reported as -41°C.

Description of key information

Two publications were available in the literature reporting a melting / freezing point for 4-methylcyclohexanone:

-41°C, melting point, method not reported, (White, 1940)

-40.6°C, freezing point, method not reported, (Chiurdoglu, 1938)

 

An additional publication which was not available reported a melting point of -42.8 °C (Sacharkin, C., Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1961, p1144). The result was not considered further.

 

Both primary data sources were assigned a Klimisch reliability rating of 4, due to the lack of experimental details reported in the publications. The values reported by the two independant research groups, measured on independently synthesised samples, at different times, are in very good agreement. As a result, in accordance with REACH, Annex XI, 1.2, this standard data requirement is considered to be met based on the weight of evidence. Overall the available data is considered to be adequate (all reported data is below -20°C), relevant, and sufficiently reliable, and no further testing is required for this endpoint. The value from White (1940) was taken forward for the purposes of risk assessment.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

-41 °C