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EC number: 947-751-9 | CAS number: -
Preliminary Test (MT 181)
The recorded observations for the contents of the cylinder after each addition of n-octanol are shown in the following table:
Total Volume of
n-Octanol Added (mL)
Saturation Concentration (g/L)
Opaque, off-white liquid with excess test substance present
Translucent, off-white liquid with excess test substance present
The solubility was estimated to be less than 10 g/L and definitive testing was continued using the adapted flask method.
Preliminary Test (Adapted Flask Method)
The preliminary estimate of the octanol solubility at 20.0 ± 0.5°C was 7.91 g/L.
Definitive Test (Adapted Flask Method)
The mean peak areas relating to the solutions are shown in the following table:
Mean Peak Area
Standard 5.10 x 103 mg/L
4.8887 x 107
Standard 4.08 x 103 mg/L
3.9186 x 107
Standard 3.06 x 103 mg/L
2.8480 x 107
Standard 2.04 x 103 mg/L
1.7266 x 107
Standard 1.02 x 103 mg/L
1.0269 x 107
Standard 510 mg/L
4.4953 x 106
1.7347 x 107
1.7032 x 107
1.9566 x 107
2.0053 x 107
2.0510 x 107
2.0400 x 107
The calibration curve from which the sample concentrations were interpolated is attached in attached background material section of the IUCLID.
The concentration (g/L) of test substance in the sample solutions is shown in the following table:
Time Shaken at
~ 30 ºC (h)
Mean concentration (based on Samples 2 and 3): 17.7 g/L at 20.0 ± 0.5ºC
As the adapted flask method preliminary test result was close to that of the loading rate value, the definitive test utilised a higher loading rate. The overall result was based on Samples 2 and 3. It was considered that Sample 1 was lower as it possibly hadn’t quite reached saturation.This result has been obtained considering the test substance as a whole. As the test substance is a complex mixture, the solubility of the individual constituents may differ.The MT-181 preliminary result suggested the solubility was less than 10 g/L and less than the definitive result; this may have been due the longer shaking times and higher temperature (30°C) used in the flask method allowing for a greater dissolution.
The octanol solubility of the test substance has been determined to be 17.7 g/L of solution at 20.0 ± 0.5°C.
A study was conducted to determine the n-octanol solubility of the test substance, 'mono- and di- C16 PSE, K+ and C16-OH and isostearyl isostearate' (100 %), according to OECD Guideline 105 and EU Methos A.6, using adapted flask method. Under the study conditions, the n-octanol solubility of the test substance was determined to be 17.7 g/L of solution at 20.0 ± 0.5°C (Envigo, 2018).
The n-octanol solubility of the test substance was determined using an adapted flask method according to OECD Guideline 105 and EU Method A.6 (Envigo, 2018).
Value used for CSA: 17.7 g/L at 20 °C
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