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EC number: 214-675-6 | CAS number: 1184-78-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented report which meets basic scientific principles. Similar to guideline study; not GLP, no information regarding gross necropsy
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Similar to guideline study; not GLP, no information regarding gross necropsy
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- BASF Internal Procedure
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- no details available
- Duration of exposure:
- 24 hours
- Doses:
- 2000, 5000 mg/kg bw
- No. of animals per sex per dose:
- 3/sex/dose
- Control animals:
- not specified
- Details on study design:
- Animals were observed for 14 days after the application of the test substance to the shaved dorsal surface of the rat.
The average weight of the animals was 221 g (males) and 180 g (females). - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: no further details available
- Mortality:
- No animals died.
- Clinical signs:
- other: Irregular breathing, staggering, spastic gait and apathy were observed. After 14 days animals were mostly free of clinical signs.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Only clinical symptons were observed: irregular breathing, staggering, spastic gait and apathy. After 14 days animals were mostly free of clinical signs.
- Executive summary:
According to an internal BASF procedure (1979), which is equivalent to OECD guideline 402 the acute dermal toxicity was investigated on 3 male and female rats each. As type of coverage occlusive was chosen, the exposure duration was 24 hours and the doses were 2000 and 5000 mg/kg bw. An LD50 greater than 5000 mg/kg bw was reported, due to the fact that no animal died at the highest dose concentration. Only clinical symptoms as irregular breathing, staggering, spatic gait and apathy were observed. After 14 days the animals were mostly free of these clinical signs.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- BASF test: The product was applied once for 24 hours to the clipped skin of the back and flank (area about 42 cm²) unchanged in a dose of 5000 , 2000 or 400 mg/kg bw. The treated area of skin was then covered with an inert foil, which was secured in position with adhesive tape. The bandage was removed after an exposure period of 24 hours; subsequently, the test substance was washed off with warm water or a mixture of water/Lutrol and dried with cellulose.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Trimethylamine
- EC Number:
- 200-875-0
- EC Name:
- Trimethylamine
- Cas Number:
- 75-50-3
- Molecular formula:
- C3H9N
- IUPAC Name:
- N,N-dimethylmethanamine
- Details on test material:
- - Name of test material (as cited in study report): Trimethylamin 45 % (liquid)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: WIGA
- Weight at study initiation: male: 221 g (mean); female: 180 g (mean)
- Diet: Herlian MRH, ad libitum
- Water: tap water ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE - Area of exposure: 42 cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Lutrol and Lutrol/water (1:1)
- Time after start of exposure: 24 h - Duration of exposure:
- 24 h
- Doses:
- 400, 2000, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: No mortalities occurred at highest dose.
- Mortality:
- No mortality occured
- Clinical signs:
- other: Systemic toxicity: irregular respiration, staggering, apathy, spastic gait. Local symptoms: after 24 h skin irritation was noted and after 14 days scaling of the skin was observed.
- Gross pathology:
- no abnormalities observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No mortality occured at highest dose rate of 5000 mg/kg bw. Only clinical symptons were observed: irregular breathing, staggering, spastic gait and apathy. After 14 days animals were mostly free of clinical signs.
- Executive summary:
BASF AG performed a test for acute toxicity by dermal application in 1979. Trimethylamine was applied once for 24 hours to the clipped skin of the back and flank (area about 42 cm²) unchanged in a dose of 5000 , 2000 or 400 mg/kg bw. The treated area of skin was then covered with an inert foil, which was secured in position with adhesive tape. The bandage was removed after an exposure period of 24 hours; subsequently, the test substance was washed off with warm water or a mixture of water/Lutrol and dried with cellulose. No mortality was observed, as well as no changes in body weight and no abnormalities in gross pathology. Clinical signs were differentiated in systemic (irregular respiration, staggering, apathy, and spastic gait) and local symptoms (skin irritation after 24 hours, scaling of the skin after 14 days).
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