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EC number: 214-675-6 | CAS number: 1184-78-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Inhalation Toxicology of Trimethylamine
- Author:
- Kinney L.A., Burgess, B. A., Chen, H. C. and Kennedy, G. L.
- Year:
- 1 990
- Bibliographic source:
- Inhalation Toxicology, 2, 41-51, (1990)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test:
2 groups of 6 male Crl:CD(SD)BR rats were exposed for single, 4h periods. The rats were observed and weighed daily for 14 d, at which time the surviving rats were sacrificed (without pathologic examination). - GLP compliance:
- not specified
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- Trimethylamine
- EC Number:
- 200-875-0
- EC Name:
- Trimethylamine
- Cas Number:
- 75-50-3
- Molecular formula:
- C3H9N
- IUPAC Name:
- N,N-dimethylmethanamine
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: supplied by the Chemicals and Pigments Department, E. I. du Pont de Nemours and Company, Inc., Belle, W.V.
- Impurities: 0.06% dimethylamine, 0.01 % monomethylamine, and 0.17% water
- Expiration date of the lot/batch: no data
- Purity test date: no data
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratory, Kingston, N.Y.
- Age at study initiation: 7-8 wk old
- Weight at study initiation: between 234 and 293 g
- Fasting period before study: not specified
- Housing: in 8 x 14 x 8 in. suspended, steel-mesh cages
- Diet: Purina Certified Rodent Chow 5002 ad libitum
- Water: ad libitum
- Acclimation period: quarantined for 1 wk prior to testing
ENVIRONMENTAL CONDITIONS
- Temperature: 23 ± 2°C
- Humidity: 50 ± 10%
- Air changes (per hr): not specified
- Photoperiod (hrs dark / hrs light): timer-controlled 12/12-h light/dark cycle.
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
no additional information
TEST ATMOSPHERE
no analysis - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- 2000 ppm and 3500 ppm
- No. of animals per sex per dose:
- six males per group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: no - Statistics:
- not applicable
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 2 000 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- ca. 3 500 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No deaths occurred following a 4-h exposure to 2000 ppm TMA, whereas 3 of 6 rats exposed to 3500 ppm died during the exposure period.
Surviving rats showed lung noise from 1 to 9 d postexposure. Rats exposed to 3500 ppm also had dry red nasal and ocular discharge during the early stages of the post exposure period. - Clinical signs:
- other: During exposure, all rats showed labored breathing, nasal and oral discharges, and neither moved nor responded to sound.
- Body weight:
- Surviving rats showed moderate to severe weight losses 1-2 d post exposure.
- Gross pathology:
- not examined
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- A 4-hour LC50 (gas) of ca. 8.58 mg/L was determined (equivalent to 3500 ppm).
- Executive summary:
In an acute inhalation study, 2 groups of 6 male Crl:CD(SD)BR rats were exposed for single, 4h periods. The tested concentrations were 2000 ppm and 3500 ppm The rats were observed and weighed daily for 14 d, at which time the surviving rats were sacrificed (without pathologic examination).
No deaths occurred following a 4h exposure to 2000 ppm TMA whereas 3 of 6 rats exposed to 3500 ppm died during the exposure period. During exposure, all rats showed labored breathing, nasal and oral discharges, and neither moved nor responded to sound. Surviving rats showed moderate to severe weight losses 1-2 d postexposure and lung noise from 1 to 9 d postexposure. Rats exposed to 3500 ppm also had dry red nasal and ocular discharge during the early stages of the postexposure period.
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