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EC number: 214-675-6 | CAS number: 1184-78-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22. Aug 1978 - 11. Oct 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
A test group consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 7 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Trimethylamine
- EC Number:
- 200-875-0
- EC Name:
- Trimethylamine
- Cas Number:
- 75-50-3
- Molecular formula:
- C3H9N
- IUPAC Name:
- N,N-dimethylmethanamine
- Details on test material:
- - Name of test material (as cited in study report): Trimethylamin 45 % (liquid)
CAS 75-50-3 (trimethylamine), purity not specified;
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: WIGA
- Weight at study initiation: male: 220 g (mean); female: 178 g (mean)
- Fasting period before study: 15 - 20 h before application
- Diet: Herlian MRH; Eggermann; Germany, ad libitum
- Water: tap water ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 215, 316, 464, 681 and 1000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: days 2-4, 7 and 13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Animals were weighed before the experiment, and then on days 2-4, 7 and 13 of the experiment. Food was withheld from animals for a period of 15-20 hours before the application of the test substance, but water was available. - Statistics:
- A probit analysis was used to determine the LD50 value.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 766 mg/kg bw
- 95% CL:
- 654 - 901
- Mortality:
- No animals died in the three lowest groups, but 3/10 and 9/10 died in the two highest dose groups. No animals died in the first hour after administration of the test substance, but animals did die within the first 24 hours.
- Clinical signs:
- other: Animals of the two highest doses showed dyspnoea, apathy, aggressiveness, staggering, tremor, spastic gait, ruffled fur, diarrhea, exsiccosis, agglutinated snouts and poor general state.
- Gross pathology:
- Animals that died:
Heart: acute dilatation and congestive hyperemia;
Lung: slight acute swelling;
Liver: peripheral lobule marking;
Stomach: corroded mucous membranes of glandular stomach, bloody content;
Intestine: atonic, corroded mucous membranes, slight hydrothorax
Any other information on results incl. tables
Mortality:
Dose (mg/kg bw) | 1 h | 24 h | 48 h | 7 days | 14 days | |||||||||||||||
male | female | male | female | male | female | male | female | male | female | |||||||||||
1000 | 0/5 | 0/5 | 4/5 | 4/5 | 4/5 | 5/5 | 4/5 | 5/5 | 4/5 | 5/5 | ||||||||||
681 | 0/5 | 0/5 | 0/5 | 1/5 | 0/5 | 1/5 | 1/5 | 2/5 | 1/5 | 2/5 | ||||||||||
464 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | ||||||||||
316 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | ||||||||||
215 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 |
Mean weight (g):
Dose (mg/kg) | gender | day 0 | day 2-4 | day 7 | day 13 | |||||||
1000 | male | 260 | 212 | 269 | 324 | |||||||
female | 190 | - | - | - | ||||||||
681 | male | 190 | 170 | 217 | 259 | |||||||
female | 170 | 160 | 188 | 208 | ||||||||
464 | male | 190 | 198 | 245 | 279 | |||||||
female | 170 | 185 | 201 | 210 | ||||||||
316 | male | 190 | 211 | 249 | 254 | |||||||
female | 170 | 189 | 203 | 214 | ||||||||
215 | male | 270 | 272 | 320 | 340 | |||||||
female | 190 | 199 | 214 | 222 |
The test substance caused systemic toxicity (including mortality) and local irritation in a dose dependend manner.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Criteria used for interpretation of results: not specified
- Conclusions:
- The test substance caused systemic toxicity (including mortality) and local irritation in a dose dependent manner.
- Executive summary:
An acute toxicity study was performed by BASF AG in 1979 comparable to the OECD Guideline 401. A test group consisting of 5 rats (strain: Sprague-Dawley)/sex was treated by single gavage application with an aqueous solution of the test substance trimethylamine. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 7 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. The initial concentrations were 215, 316, 464, 681, and 1000 mg/kg bw. As effect level LD50 was 766 mg/kg bw. No animals died in the three lowest groups, but 3/10 and 9/10 died in the two highest dose groups. No animals died in the first hour after administration of the test substance, but animals did die within the first 24 hours. Animals of the two highest doses showed dyspnoea, apathy, aggressiveness, staggering, tremor, spastic gait, ruffled fur, diarrhea, exsiccosis, agglutinated snouts and poor general state. The test substance caused systemic toxicity (including mortality) and local irritation in a dose dependend manner.
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