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EC number: 214-675-6 | CAS number: 1184-78-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, not GLP
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- concentration of sludge 30mg/l
- Duration of test (contact time):
- 14 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Reference substance:
- aniline
- Parameter:
- % degradation (O2 consumption)
- Value:
- 92
- Sampling time:
- 14 d
- Details on results:
- Degree of biodegradation: 92% (NH3) by BOD; 66% (NO2) by BOD
- Results with reference substance:
- no data given.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- 92 % degradation has occured within 14 days, based on O2 consumption for trimethylamine.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See attached document in section 13 "Assessment reports" for rationale and justification of the analogy approach.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 94
- Sampling time:
- 14 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Based on the analogy approach between the two substances TMAO and TMA, they are expected to have the same behavior in environmental in aquatic compartment. Hence, the trimethylamine N-oxide was considered ready biodegradable as the source substance, the trimethylamine.
- Executive summary:
Based on their physico-chemical properties, the two substances showed similarity on their structure except the oxygen in the TMAO. Both of the two substances are soluble in water. The Log Kow values for the two substances are lower than 0. The two substances could be found in environmental aqueous compartments due to their physico-chemical properties. Additionally, Henry’s law constant were calculated. The transfer from water to air compartments is considered to be slow, even negligible. QSAR were performed on TMAO (ready biodegradability and toxicity to fish, daphnia and algae). Similar results were found for target compared to experimental values obtained on the source substance : readily biodegradable (by Biowin and Vega), fish acute toxicity > 100 mg/L (Ecosar and Vega), daphnia acute toxicity: 10-100 mg/L (Ecosar and Vega), algae acute toxicity >100 mg/L (Ecosar), daphnia chronic toxicity: 1-10 mg/L (Ecosar), algae chronic toxicity: 10-100 mg/L (Ecosar).
Hence, the trimethylamine N-oxide was considered ready biodegradable as the source substance, the trimethylamine.
Referenceopen allclose all
Description of key information
The source substance (N,N-dimethylmethanamine) was tested in OECD 301C method. Concentration of sludge was 30 mg/L and substance was tested at 100 mg/L. Biodegradation was followed by O2 consumption during 14 days. Biodegradation rate at 14D: 92% (NH3) by BOD; 66% (NO2) by BOD.
Based on their physico-chemical properties, the two substances showed similarity on their structure except the oxygen in the TMAO. Both of the two substances are soluble in water. The Log Kow values for the two substances are lower than 0. The two substances could be found in environmental aqueous compartments due to their physico-chemical properties. Additionally, Henry’s law constant were calculated. The transfer from water to air compartments is considered to be slow, even negligible. QSAR were performed on TMAO (ready biodegradability and toxicity to fish, daphnia and algae). Similar results were found for target compared to experimental values obtained on the source substance : readily biodegradable (by Biowin and Vega), fish acute toxicity > 100 mg/L (Ecosar and Vega), daphnia acute toxicity: 10-100 mg/L (Ecosar and Vega), algae acute toxicity >100 mg/L (Ecosar), daphnia chronic toxicity: 1-10 mg/L (Ecosar), algae chronic toxicity: 10-100 mg/L (Ecosar).
Hence, the trimethylamine N-oxide was considered ready biodegradable as the source substance, the trimethylamine.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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