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EC number: 282-780-4
CAS number: 84418-68-8
In this study, neodecanoic acid was examined for skin sensitization
potential in the guinea pig maximization procedure of Magnusson and
A preliminary screen was carried out to determine the concentrations of
test material to be used for intradermal induction, topical induction,
and topical challenge. Two male and female guinea pigs
were used for each test concentration.
Groups of ten male and ten female guinea pigs were used for the test and
a further five males and five females as controls.
Induction was accomplished in two stages.
1) Intradermal injection
Two rows of three injections were made, one on each side of the midline
in the shorn skin of the shoulder region.
2) Topical application
One week after the intradermal injections, the same area was clipped
free from hair. A 4x4 cm patch of filter paper was
soaked in a solution of the test material and placed over the injection
sites and covered with an occlusive dressing. The
dressing was left in place for 48 hours.
The challenge procedure was carried out two weeks after topical
induction. Challenge was accomplished by topical
application of the test material to the flank of animals via an occluded
patch. The challenge lasted 24 hours.
Immediately after the challenge, and then again at 24 and 48 hours
later, each animals was examined for signs of skin sensitization.
At no point was there any evidence of skin sensitization produced by
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