Registration Dossier
Registration Dossier
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EC number: 248-383-5 | CAS number: 27277-00-5
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
The test substance can inhibit gastric emptying in mice, rats and monkeys.
The test substance has antibronchoconstrictor activity in guinea-pigs.
The test substance can inhibit the activity of cyclic 3',5'-AMP phosphodiesterase.
The test substance has little effect on the cardiovascular or respiratory systems.
Additional information
Gastric emptying in mice, rats and monkeys was inhibited by the test substance given orally at 2.5, 1.0, and 0.2 mg/kg body weight. Subcutaneous dosing of 1.0 mg/kg bw also inhibited gastric emptying in mice and rats (Wright et al., 1979). Furthermore the test substance has an antibronchoconstrictor activity in guinea-pigs. In vitro, the test substance inhibits the activity of cyclic 3',5'-AMP phosphodiesterase. Finally, the test substance was tested in vivo in dogs and cats to determine the effect on the cardiovascular or respiratory system. It was concluded that the test substance has little effect on the cardiovascular or respiratory systems (Farrell, 1970a).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
