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Short-term toxicity to fish

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Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
Justification is provided in the separate statement.
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
62.4 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Validity criteria fulfilled:
yes
Conclusions:
No study is available on The test item. Two studies from supporting substance (structural analogue or surrogate) are available.

In this static limit test according OECD 203 the test item Sodium-N-cocoyl glycinate (a.i content of solution 29.8% ww) did not cause any effects to zebrafish after 96h when tested with a nominal concentration of 100 mg/L (29.8 mg/L a.i.). LC0 and NOEC are 100 mg/L (29.8 mg/L a.i.). LC100 is > 100 mg/L (> 29.8 mg/L a.i.).

In a static test according OECD 203 the test item Sodium N-octoyl glutamate the LC50 of the test item was found to be 150 mg/L test item or 62.4 mg/L a.i.
Executive summary:

No study is available on The test item. Two studies from supporting substance (structural analogue or surrogate) are available.

In this static limit test according OECD 203 the test item Sodium-N-cocoyl glycinate (a.i content of solution 29.8% ww) did not cause any effects to zebrafish after 96h when tested with a nominal concentration of 100 mg/L (29.8 mg/L a.i.). LC0 and NOEC are 100 mg/L (29.8 mg/L a.i.). LC100 is > 100 mg/L (> 29.8 mg/L a.i.).

In a static test according OECD 203 the test item Sodium N-octoyl glutamate the LC50 of the test item was found to be 150 mg/L test item or 62.4 mg/L a.i.

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1990-01-22 to 1990-03-05
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method C.1 (Acute Toxicity for Fish)
GLP compliance:
yes
Analytical monitoring:
no
Vehicle:
no
Details on test solutions:
PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The test substances was directly added to the test vessels.
Test organisms (species):
Leuciscus idus
Details on test organisms:
TEST ORGANISM
- Common name: orfe
- Source: Fish farm Eggers, Hohenwestedt
- Age at study initiation: approx. 4 weeks
- Corpulence factor: 0.8 - 1.1 g/cm^3
- Feeding during test: none

ACCLIMATION
- Acclimation period: For at least 7 days
- Acclimation conditions: same dilution water
- Type and amount of food: Pitti Floxi-Flocken Alleinfutter für Zierfische
- Feeding frequency: twice a week
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
15 ± 3° dH (total hardness)
Test temperature:
20 ± 0.5 °C
pH:
7.3 - 8.2
Dissolved oxygen:
4.4 - 8.6 mg/L
Nominal and measured concentrations:
Nominal concentration: 150, 175, 190 and 200 mg/L (based on test material)
Nominal concentration: 48, 56, 60.8 and 64 mg/L (based on active matter)
Details on test conditions:
TEST SYSTEM
- Test vessel: tanks (L 28.5 cm / W 21.0 cm / H 24.0 cm)
- Material: glass; Fill volume: 15 L
- Aeration: weak aeration during test period
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- Biomass loading rate: 3.7 fish/L

TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: mixture of drinking water and deionized water
- Ca/mg ratio: 4:1
- Culture medium different from test medium: no
- Intervals of water quality measurement: Oxygen concentration and pH were measured after 24, 48, 72 and 96 h test duration.

EFFECT PARAMETERS MEASURED: Mortality was recorded after 24, 48, 72 and 96 h test duration.

TEST CONCENTRATIONS
- Spacing factor for test concentrations: approx. 1.1
Reference substance (positive control):
no
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
62.4 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Remarks on result:
other: converted to active matter
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
195 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
190 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
200 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
- Mortality of control: none
Validity criteria fulfilled:
yes
Conclusions:
The LC50 of the test item was found to be 62.4 mg/L a.i.
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
2008-08-21 to 2008-08-25
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Analytical monitoring:
yes
Details on sampling:
0, 96h
Vehicle:
no
Details on test solutions:
direct weighing, limit test at 100 mg/L test item (29.8 mg/L a.i.)
Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
96 h
Hardness:
Total Hardness 59 mg/L as CaCO3
Test temperature:
22.3 degree C
pH:
7.23-7.62
Dissolved oxygen:
Oxygen saturation 95-100%
Nominal and measured concentrations:
nominal 100 mg/L test item concentration, 16.6 mg/L DOC of test media
Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
> 29.8 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
29.8 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
29.8 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
> 100 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
100 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
100 mg/L
Nominal / measured:
meas. (initial)
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Validity criteria fulfilled:
yes
Executive summary:

In this static limit test according OECD 203 the test item Hostapon SG (a.i content of solution 29.8% ww) did not cause any effects to zebrafish after 96h when tested with a nominal concentration of 100 mg/L (29.8 mg/L a.i.). LC0 and NOEC are 100 mg/L (29.8 mg/L a.i.). LC100 is > 100 mg/L (> 29.8 mg/L a.i.).

Validity criteria on Oxygen saturation (>= 60%) and Mortality in the control (0%) were met.

Description of key information

LC50 (96h) = 62.4 mg/L (nominal, based on active matter) for Leuciscus idus (OECD 203, read across)

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
62.4 mg/L

Additional information

No study is available on The test item. Two studies from supporting substance (structural analogue or surrogate) are available.

In this static limit test according OECD 203 the test item Sodium-N-cocoyl glycinate (a.i content of solution 29.8% ww) did not cause any effects to zebrafish after 96h when tested with a nominal concentration of 100 mg/L (29.8 mg/L a.i.). LC0 and NOEC are 100 mg/L (29.8 mg/L a.i.). LC100 is > 100 mg/L (> 29.8 mg/L a.i.).

In a static test according OECD 203 the test item Sodium N-octoyl glutamate the LC50 of the test item was found to be 150 mg/L test item or 62.4 mg/L a.i.