Registration Dossier
Registration Dossier
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EC number: 947-945-3 | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unexpected anaphylaxis to cashew nut
- Author:
- O. Quercia*, S. Rafanelli, L. Marsigli, F. G. Foschi, G. F. Stefanini
- Year:
- 1 999
- Bibliographic source:
- Allergy 54,892-902
Materials and methods
- Principles of method if other than guideline:
- Allergy to the cashew nut in human case report.
- GLP compliance:
- not specified
- Type of study:
- other: anaphylaxis to cashew nut
Test material
- Reference substance name:
- 8007-24-7
- Cas Number:
- 8007-24-7
- IUPAC Name:
- 8007-24-7
- Details on test material:
- - Name of test material (as cited in study report):Cashew nut
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Sex:
- male
- Details on test animals and environmental conditions:
- Not available
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: not applicable
- Vehicle:
- no data
- Concentration / amount:
- Not available
Challengeopen allclose all
- Route:
- other: not applicable
- Vehicle:
- no data
- Concentration / amount:
- Not available
- No. of animals per dose:
- Not applicable
Results and discussion
Any other information on results incl. tables
A patient allergic to pistachio who had anaphylaxis due to cashew nuts. A 42- year-old white man was admitted to our emergency room complaining of mouth and lip itching, slurred voice, dyspnea, and vomiting a few minutes after eating some cashew nuts. Prompt treatment with steroids, antihistamines, and epinephrine relieved the patient's symptoms, leading to a complete recovery in about 24 h.
Three years later, the patient complained of the same symptoms while eating pasta with a sauce based on garlic, basil, and pine nuts and attributed the symptoms to pine nuts and basil. After a few months, mouth itching and vomiting occurred again when the patient ate pistachio nuts.
To diagnose an adverse reaction to Anacardiaceae, a skin prick by prick test was performed with a positive result for pistachio and cashew nut.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- Based on the allergic reactions developed by human due to intake of pistacio and cashew nuts (cashew nut shell liquid being the extract of cashew nut)belonging to the family Anacardiaceae it is concluded that cashew nut shell liquid is a skin sensitiser.
- Executive summary:
As illustrated in the case report a patient allergic to pistachio who had anaphylaxis due to cashew nuts reported mouth and lip itching, slurred voice, dyspnea, and vomiting.Three years later, the patient complained of the same symptoms while eating similar products belonging to the family Anacardiaceae. Based on the allergic reactions developed by human due to intake of pistacio and cashew nuts (cashew nut shell liquid being the extract of cashew nut)belonging to the family Anacardiaceae it is concluded that cashew nut shell liquid is a skin sensitiser.
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