Registration Dossier
Registration Dossier
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EC number: 285-089-6 | CAS number: 85029-63-6
Endpoint summary
Administrative data
Description of key information
Hydrolysis: Data waiving according to REACH Annex VIII, column 2 (substance is readily biodegradable)
Biodegradability: readily biodegradable (76.5% within 28 days)
Adsorption / desorption: Data waiving according to REACH Annex VIII, column 2 (the substance and its relevant degradation products decompose rapidly) // Koc = 107.4 L/kg; log Koc = 2.03 (dimensionless) (calculated)
Additional information
Ready Biodegradability
A reliable key study is available on the ready biodegradability of the submission substance according to OECD 301F and in compliance with GLP (RL1). The test item was investigated for its ready biodegradability in a manometric respirometry test over a period of 28 days. The biodegradation was followed by the oxygen uptake of the microorganisms during exposure. Degradation rate of test item was calculated from the oxygen consumption by the aerobic activated sludge microorganisms after 28 days of incubation. The mean biodegradation at test end after 28 days was 76.5% (based on ThOD_NH4). Therefore, the test item is considered to be readily biodegradable. In conclusion, the submission substance is expected to biodegrade fast in the environment.
Adsorption / desorption (supporting information)
In a supporting study, QSAR (KOCWIN v. 2.00 included in EPI Suite TM v4.1 (EPA, 2011)) was applied for estimation of organic carbon normalized adsorption coefficient (Koc). The applicability domain of the valid KOCWIN model (see attached QMRF) generally comprises constituents of the UVCB submission substance. A structure representative for constituents of the UVCB was used for Koc estimation. The geometric mean value of results from a) MCI Method (53.04 L/kg) and b) log Kow based method (217.6 L/kg) was taken as the final result: Koc = 107.4 L/kg / log Koc = 2.03 (dimensionless). According to the calculated log Koc of 2.03, the submission substance is not expected to adsorb to sludge, soil or sediment.
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