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EC number: 907-713-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996-12-10 - 1998-04-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- This information is used for read-across to Reaction mass of 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)pent-1-en-3-one and 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)pent-1-en-3-one.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Remarks:
- BASF AG, Department of Toxicology
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Mixture of Methyl ionone isomers
- IUPAC Name:
- Mixture of Methyl ionone isomers
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - age: young adult
- weights at start of study: 150-300 g (+/- 20% of mean weight)
- identification: individual identification using cage cards and group identification by tail marking
- housing: single housing in fully air-conditioned rooms, central air conditioning guaranteed a range of 20-24°C for temperature and of 30-70% for relative humidity. There were no deviations from these ranges which influenced the results of the study.
- day/night rhythm: 12:12
- type of cage: stainless steel wire mesh cages, type DK-III
- bedding: no bedding in the cages, sawdust in the waste trays
- drinking water: tap water ad libitum per day
- diet: Kliba-Labordiät 343, Klingentalmühle AG, Kaiseraugst, Switzerland, ad libitum
- analysis of drinking water: the drinking water is regularly assayed for chemical contaminants by municipal authorities of Frankenthal and the technical services of BASF AG as well as for the presence of germs by a contract laboratory
- analysis of feed: the feed used in the study was assayed for chemical and microbiological contaminants
- acclimatization period: acclimatization for at least 1 week
- fasting period: the animals were given no feed at least 16 hours before administration, but water was available ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: olive oil DAB 10
- Details on oral exposure:
- - reason for the vehicle: test substance could not be homogeneously distributed in aqua bidest
- form of administration: solution
- amounts administered: dose: 2000 mg/kg; concentration: 40 g/100 ml; administration volume: 5 ml/kg
- time of day of administration: in the morning - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - observation period: 17 days for males / 14 days for females
- body weight determination: individual body weights shortly before application (day 0), weekly thereafter and at the end of the study (before fasting period)
- signs and symptoms: recording of signs and symptoms several times on the day of administration and at least once each workday for the indiviual animals
- mortality: a check for any dead or moribund animals was made twice each workday and once on saturdays, sundays and on public holidays
- pathology: necropsy at the last day of the observation period; withdrawal of food at least 16 hours before killing with CO2; then necropsy with grosspathology examination; necropsy of all animals that died before end of study as early as possible
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50 cut-off
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- no mortalities observed
- Mortality:
- no mortality to day 14 (females) and day 17 (males)
- Clinical signs:
- other: see table
- Gross pathology:
- necropsy findings of sacrificed animals: organs without particular findings (3 males, 3 females)
- Other findings:
- clinical symptoms reversible
Any other information on results incl. tables
animal symptoms:
males |
females |
|||
cageside observations |
number of animals |
cageside observations |
number of animals |
|
impaired general state | H1 - H4 |
3 |
H0 - H2 |
2 |
poor general state | H0 - D2 |
3 |
||
dyspnoea | H1 - H4 |
3 |
H0 - D2 |
3 |
apathy | H0 - D2 |
3 |
||
staggering | H1 - H4 |
3 |
H0 - D2 |
3 |
twitching | H4 |
1 |
||
saltatory spasm | H1 - H3 |
1 |
||
spastic gait | D1 - D2 |
1 |
||
piloerection | H0 - D2 |
3 |
||
smeared fur | D2 |
1 |
||
exophthalmos | H0 - H1 |
3 |
||
S5 | D2 |
1 |
H: hour
D: day
S5: red smeared fur in the anogenital area
body weights:
day |
||||
|
0 |
7 |
13 |
|
male |
1 |
175 |
244 |
273 |
2 |
175 |
230 |
263 |
|
3 |
175 |
230 |
281 |
|
mean |
175 |
235 |
272 |
|
female |
1 |
170 |
202 |
210 |
2 |
171 |
194 |
215 |
|
3 |
172 |
203 |
215 |
|
mean |
171 |
200 |
213 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- according to EU CLP (EC No. 1272/2008, and its amendments) too
- Conclusions:
- The oral acute toxicity of methylionone was tested in a study under GLP performed according to OECD Guideline 423 (BASF, 1999). Three male and three female Wistar rats were once administered by gavage with 2000 mg/kg bw in 5 ml/kg bw olive oil DAB 10. The following observation time was 17 days for males and 14 days for females. Although signs of toxicity were noted during the first days after application, the animals appeared normal after five days. Since no mortality was observed, the LD50 cut-off value was determined to be 5000 mg/kg bw.
- Executive summary:
In an acute oral toxicity study according to OECD TG 423 and GLP, groups of rats (3 per sex) were exposed to 2000 mg/kg bw test substance and observed for signs of toxicity and clinical signs for a period of 14 day (males) to 17 days (females). Signs of toxicity noted in the male and female animals were impaired general state, dyspnoea and staggering. The male animals also showed saltatory spasm. The female animals additionally exhibited poor general state, apathy, twitching, spastic gait and exophthalmos. The animals appeared normal within 5 days after application. The expected body weight gain was observed in the course of the study. No mortality occurred. No abnormalities were noted at necropsy of animals sacrificed at the end of the study.
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