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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Remarks:
Guinea Pig Maximisation Test (GPMT)
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1997
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
2006

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
The method was in place before the LLNA method.

Test material

Constituent 1
Chemical structure
Reference substance name:
1-Tetradecanol
Cas Number:
112-72-1
Molecular formula:
C14H30O
IUPAC Name:
1-Tetradecanol

In vivo test system

Test animals

Species:
guinea pig

Results and discussion

In vivo (non-LLNA)

Results
Remarks on result:
other: no detailed results provided
Remarks:
No skin sensitisation reactions were observed for the category of linear and essentially linear alcohols.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
No skin sensitisation reactions were observed for the category of linear and essentially linear alcohols. The weight of the evidence indicates that this category does not have a skin sensitisation potential in guinea pigs.
Executive summary:

References: Iihama, 1997b. The maximization test for contact hypersensitivity potential of Kalcol 4098 in guinea pigs. Test Number 9719.