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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Remarks:
Guinea Pig Maximisation Test (GPMT)
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1997
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
2006

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
The method was in place before the LLNA method.

Test material

Constituent 1
Chemical structure
Reference substance name:
1-Tetradecanol
Cas Number:
112-72-1
Molecular formula:
C14H30O
IUPAC Name:
1-Tetradecanol

In vivo test system

Test animals

Species:
guinea pig

Results and discussion

In vivo (non-LLNA)

Results
Remarks on result:
other: no detailed results provided
Remarks:
No skin sensitisation reactions were observed for the category of linear and essentially linear alcohols.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
No skin sensitisation reactions were observed for the category of linear and essentially linear alcohols. The weight of the evidence indicates that this category does not have a skin sensitisation potential in guinea pigs.
Executive summary:

References: Iihama, 1997b. The maximization test for contact hypersensitivity potential of Kalcol 4098 in guinea pigs. Test Number 9719.