Sulfuric acid, C16-C18 (even numbered) alkyl esters, sodium salts and C16-18 (even numbered) alcohols

Skin sensitisation

Administrative data

Endpoint:

skin sensitisation: in vivo (non-LLNA)

Remarks:

Guinea Pig Maximisation Test (GPMT)

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1997

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

2006

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 406 (Skin Sensitisation)

Type of study:

guinea pig maximisation test

Justification for non-LLNA method:

The method was in place before the LLNA method.

Test material

Test material information

Constituent 1

Reference substance name:

1-Tetradecanol

Cas Number:

112-72-1

Molecular formula:

C14H30O

IUPAC Name:

1-Tetradecanol

In vivo test system

Test animals

Species:

guinea pig

Results and discussion

In vivo (non-LLNA)

Results

Remarks on result:

other: no detailed results provided

Remarks:

No skin sensitisation reactions were observed for the category of linear and essentially linear alcohols.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

No skin sensitisation reactions were observed for the category of linear and essentially linear alcohols. The weight of the evidence indicates that this category does not have a skin sensitisation potential in guinea pigs.

Executive summary:

References: Iihama, 1997b. The maximization test for contact hypersensitivity potential of Kalcol 4098 in guinea pigs. Test Number 9719.