Registration Dossier
Registration Dossier
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EC number: 221-411-3 | CAS number: 3087-37-4
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Comparison of Behavioral Teratogenic Effects of Ethanol an N-Propanol administered by Inhalation to Rats
- Author:
- Nelson B.K., Brightwell W.S., Burg J.R
- Year:
- 1 985
- Bibliographic source:
- Neurobehavioral Toxicology and Teratology, Vol. 7, 779-783
- Reference Type:
- publication
- Title:
- Behavioral Teratology Investigation of 1-Propanol Administered by Inhalation to Rats
- Author:
- Nelson B.K., Brightwell W.S., Taylor B.J., Khan A., Burg J.R., Krieg E.F., Massari V.J.
- Year:
- 1 989
- Bibliographic source:
- Neurotoxicol.Teratol. 11, 153-159
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: other
- Principles of method if other than guideline:
- Male animals were treated for 42 days, then mated with untreated virgin females . Resulting pregnant females were sham exposed on gestation days 1-19 (experiment 1). Another group of untreated males and females were mated. Resulting pregnant females were then exposed to the test substance on gestation days 1-19 (experiment 2).
- GLP compliance:
- no
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- Molecular formula:
- C3H8O
- IUPAC Name:
- propan-2-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure (if applicable):
- whole body
- Vehicle:
- air
- Duration of treatment / exposure:
- Experiment 1
- Males : 6 weeks premating
- Females: sham exposed
Experiment 2
- Males: sham exposed
- Females: day 1-19 of gestation - Frequency of treatment:
- 7 h/day. 7 days/week.
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 mg/m³ air (nominal)
- Dose / conc.:
- 8 730 mg/m³ air (nominal)
- Dose / conc.:
- 17 460 mg/m³ air (nominal)
- Dose / conc.:
- 24 940 mg/m³ air (nominal)
- No. of animals per sex per dose:
- female 15; male 18
Results and discussion
Results: P0 (first parental generation)
Reproductive function / performance (P0)
- Reproductive function: oestrous cycle:
- no effects observed
Effect levels (P0)
- Key result
- Dose descriptor:
- NOAEC
- Effect level:
- ca. 8 730 mg/m³ air (nominal)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: Based on the reversible fertility effects
Results: F1 generation
Effect levels (F1)
- Key result
- Dose descriptor:
- NOAEC
- Generation:
- F1
- Effect level:
- ca. 3 500 ppm (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- clinical signs
Overall reproductive toxicity
- Key result
- Reproductive effects observed:
- no
- Lowest effective dose / conc.:
- 8 730 mg/m³ air
- Treatment related:
- no
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
