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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Not reported
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Reliability has been presented as 2 because similar to OECD Guideline protocol has been followed but not GLP.
Justification for type of information:
This information is used for read across to Geranyl Isobutyrate MCS.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report date:
1972

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
no details on test material (purity not indicated), no details on test animals and environmental conditions
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Citronellyl butyrate
EC Number:
205-463-4
EC Name:
Citronellyl butyrate
Cas Number:
141-16-2
Molecular formula:
C14H26O2
IUPAC Name:
3,7-dimethyloct-6-en-1-yl butyrate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
No details.

ENVIRONMENTAL CONDITIONS
No details.

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No details.
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10 (no sex specified)
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data
Statistics:
Not performed.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
Three animals died on day 1.
Clinical signs:
Slow respiration, lethargy and death overnight.
Body weight:
No data.

Any other information on results incl. tables

 Dose mg/kg No. of deaths  Observation day                                        
     1 10  11  12  13  14 
 5000  0/10  3  0  0  0  0  0  0  0  0  0  0  0  0  0

Applicant's summary and conclusion

Interpretation of results:
other: Not acute harmful
Remarks:
according to EU CLP (EC No. 1272/2008 and its amendments).
Conclusions:
An LD50 of >5000 mg/kg bw was determined in this acute oral toxicity study with rats.
Executive summary:

In an acute oral toxicity study one group of 10 rats was orally exposed to 5000 mg/kg bw of the substance. The rats were observed for signs of toxicity and clinical signs for a period of 14 days. Three animals died on day 1 of the observation period. Slow respiration and lethargy was observed. Based on the results, an LD50 of > 5000 mg/kg bw was determined in the acute oral toxicity study with rats.