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Diss Factsheets
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EC number: 203-117-7 | CAS number: 103-49-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995-02-13 to 1995-02-17
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- Principles of method if other than guideline:
- At defined concentrations of a substance arise after the test period different percentages of dead fish. The LC 0 and LC 100 values were determined directly, while the LC 50 value is determined by calculation or graphically from the concentration-response curve.
The test duration is 96 hours. - GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Test concentrations: 5, 10, 20, 40 and 80 mg/L
- direct weighing - Vehicle:
- no
- Details on test solutions:
- - Conditions: static test according to the Guideline
- Light-dark phase: 16 h light / 8h dark
- Test procedure: Test aquaria 300 x 135 x 200 mm; 5 L test medium, ventilated; static
- Tools: Magnetic - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- - Type: zebrafish (Danio rerio HAMILTON BUCHANAN)
- Origin: West Aquarium (Bad Lauterberg)
- Date of birth: 1994-09-11
- Ship Date: 1994-12-06
- Body length: 2.5 - 3.5 cm
- Storage under certain conditions: SOP 4001
- Mortality at storage: <2 %
- Medical treatment: no
- Water quality at storage: synthetic freshwater according to ISO - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 14.3 °dH
- Test temperature:
- Control: 21.3 - 21.8 °C
Test item: 21.4 - 21.7 °C - pH:
- Control: 7.6 - 8.1
Test item: 7.7 - 8.1 - Dissolved oxygen:
- Control: 8.4 - 9.0 mg/L
Test item: 8.5 - 9.3 mg/L - Nominal and measured concentrations:
- Nominal concentrations: 5, 10, 20, 40 and 80 mg/L
- Details on test conditions:
- The substance was weighed in water to produce the individual test concentrations stirred for 3 hours on a magnetic stirrer.
The result specification refers to the substance, calculated from the measured TOC values (1 mg/L TOC is equivalent 1.2 mg/L test substance). - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 10.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 42.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 21.4 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Geometric mean: LC0 / LC100 : LC50 = 21.4 mg/L
- Validity criteria fulfilled:
- yes
- Conclusions:
- The arithmetic mean of LC0 / LC100 was calculated as LC50 = 21.4 mg/L after 96 hours esposure.
- Executive summary:
The acute toxicity of dibenzylamine to Fish (Danio rerio) was determined in a 96 -hour static test according to EU method C.1 'Acute toxicity for Fish' (1992). Under the conditions of the present study, the 96 -h LC50 (arithmetic mean) was calculated as 21.4 mg/L.
Reference
Description of key information
The study of Bayer (1995) investigating the acute toxicity of dibenzylamine to fish according to EU Method C.1 was considered as the key study for endpoint coverage (klimisch score of 2). An EC50 of 21.4 mg/L (based on arithmetic mean concentration) was obtained after an exposure of 96 hours in a static test in freshwater.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 21.4 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.