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EC number: 213-995-3 | CAS number: 1071-76-7
As the target substance hydrolyses rapidly (half-life < 5 minutes) the intrinsic properties are related to hydrolysis products of the target substance. The toxicity evaluation of the hydrolysis product – 1-butanol was used for assessment.
Oral The most sensitive indicator of oral effect was ataxia and hypoactivity at 500 mg/kg bw /d, the highest dose tested; this is typical of alcohol CNS depression. There was no clear evidene of other systemic toxicity. Slight effects on haematological parameters were noted in female rats at 500 mg/kg bw/d after 6 weeks, but not after 13 weeks of dosing. The NOAEL was 125 mg/kg bw/d. (US EPA 1986)
In an inhalative study at 50 and 100 ppm level, neurological effects were observed. Neurological effects were assessed by rotarod performance. The LOEL was 50 ppm (Korsak et al. 1994).
In another inhalative study incorporating structure surrogate, n-butyl acetate (NBAc), rats were exposed to 500, 1500 and 3000 ppm NBAc for 13 weeks. No systemc, organ-specific toxicit was observed. A NOAEL of 500 ppm was reported fro systemic effects in rats (David et al., 1998) The equivalent values for 1-butanol, corrected for molecular weight, was 223 ppm (equivalent to 676 mg/m3). (Adapted from UNEP 2004)
No adequate dermal study was available for 1-butanol.
Based on the NOAEL (oral) and NOAEC (inhalation) 1 -butanol, there is no need for classification of the target substance in accordance with the criteria of CLP Regulation.
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