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Ecotoxicological information

Toxicity to microorganisms

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Endpoint:
activated sludge respiration inhibition testing
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Justification for type of information:
The target substance is hydrolytically unstable with hydrolysis half-life less than 5 minutes. The hydrolysis products have been identified to be 1-butanol and hydrated zirconium dioxide. The properties and toxiciteis of the hydrolysis products are therefore used for read-across.
Endpoint:
toxicity to microorganisms, other
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to
Guideline:
other: other
Principles of method if other than guideline:
Serum bottle test (closed system)
GLP compliance:
not specified
Analytical monitoring:
no
Test organisms (species):
other: aerobic heterotrophic bacteria
Test type:
static
Water media type:
freshwater
Total exposure duration:
24 h
Key result
Duration:
24 h
Dose descriptor:
EC50
Effect conc.:
ca. 3 980 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Validity criteria fulfilled:
yes
Conclusions:
24 h EC50 to Aerobic heterotrophic bacteria of 1-butanol was 3980 mg/l
Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
according to
Guideline:
other: DIN 38412, part 8 (Pseudomonas Zellvermehrungshemm-Test)
GLP compliance:
no
Test organisms (species):
Pseudomonas putida
Test type:
static
Water media type:
freshwater
Total exposure duration:
16 h
Key result
Duration:
16 h
Dose descriptor:
other: toxicity threshold
Effect conc.:
ca. 650 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: mean extinction value
Validity criteria fulfilled:
yes
Conclusions:
16 h toxicity threshold of 1butanol to Pseudomonas putida is 650 mg/l/

Description of key information

Key value for chemical safety assessment

EC50 for microorganisms:
3 980 mg/L
EC10 or NOEC for microorganisms:
650 mg/L

Additional information

No studies were conducted on the target substance, Zirconium tetrabutanolate. As the target substancehydrolyses rapidly (half-life < 5 minutes) the intrinsic properties are related to hydrolysis products of thetarget substance.

On the basis that if entering the environmental, this substance will quickly dissociate to form the inorganic(poorly soluble) zirconium dioxide and well-evaluated organic substances - 1 -butanol.
The zirconium dioxide is not considered further in this report as aquatic toxicity assessments do not apply.

The lower value of 16h toxicity threshold to Pseudomonas putida celll multiplicaition inhibtion test (Bringmann and Kuehn, 1980) was used for CSA..