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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October from 08th to 12th, 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Reason / purpose:
reference to other study
Remarks:
validated of analytical method
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
adopted July 27, 1995
Deviations:
yes
Remarks:
not impacting the reliability of test results
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Water solubility:
131 g/L
Conc. based on:
test mat.
Incubation duration:
24 - 72 h
Temp.:
20 °C
pH:
ca. 4.4
Details on results:
The measured concentrations are constant within ± 15 % and thus within the range required by the guidelines.
The water solubility of test item was determined to be 131 ± 10 g/l (95 % confidence interval) at 20 ± 1 °C using the shake-flask method for the performance.

Sampling time  Measured concentration (g/l) Measured pH
Test vessels Mean with the 95 % confidence intervals
After 24 h 128 127 ± 3 4.42
126 4.44
126 4.44
After 48 h 129 131 ± 16 4.4
139 4.38
126 4.42
After 72 h 132 135 ± 14 4.37
141 4.35
131 4.39
Solubility of the test item (g/l) 131 ± 10 -
RSD % 3 -
Ultra-pure water not detected 6.08-6.10
Conclusions:
131 ± 10 g/l at 20 ± 1 °C and pH ca 4.4
Executive summary:

The water solubility of the test item was determined in accordante with the method and procedures outlined into the OECD guideline 105.

A preliminary test for solubility was carried out for the decision whether the column elution method or the flask method has to be used for the performance of the main test. The solubility of the test item was higher than 10 mg/l; therefore, the flask method was used for the main test.

The concentration in the clear aqueous phase was determined by spectrophotometric validate method. The pH of each sample was recorded.

The water solubility of test item was determined to be 131 ± 10 g/l (95 % confidence interval) at 20 ± 1 °C and pH ca 4.4 using the flask method for the performance. The measured concentrations are constant within ± 15 % and thus within the range required by the guidelines.

Conclusion

Water solubility: 131 ± 10 g/l at 20 ± 1 °C and pH ca 4.4

Description of key information

131 ± 10 g/l at 20 ± 1 °C and pH ca 4.4

Key value for chemical safety assessment

Water solubility:
131 g/L
at the temperature of:
20 °C

Additional information

OECD 105 - Flask method