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Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1970s-1980s
Reliability:
2 (reliable with restrictions)
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
GLP compliance:
no
Test type:
fixed dose procedure
Specific details on test material used for the study:
AGS is administrated in a peanut oil solution
Species:
rat
Strain:
Wistar
Sex:
male
Route of administration:
oral: gavage
Vehicle:
peanut oil
Doses:
4830 mg/kg bw administrated in 0.01 ml (solution in peanut oil)/g bw
No. of animals per sex per dose:
10
Control animals:
not specified
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 4 830 mg/kg bw
Based on:
act. ingr.
Interpretation of results:
GHS criteria not met
Conclusions:
no oral toxicity
Executive summary:

At the concentration of 0.01 mg/g bw (Wistar male rats), the results obtained support the conclusion that AGS may be considered non-hazardous

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1970s-1980s
Reliability:
2 (reliable with restrictions)
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
Deviations:
yes
GLP compliance:
no
Test type:
fixed dose procedure
Specific details on test material used for the study:
AGS is administrated in peanut oil
Species:
mouse
Strain:
Swiss
Sex:
male
Route of administration:
oral: gavage
Vehicle:
peanut oil
Doses:
4830 mg/kg bw administrated in 0.01 ml (solution in peanut oil)/g bw
No. of animals per sex per dose:
10
Control animals:
not specified
Sex:
male
Dose descriptor:
LD50
Effect level:
> 4 830 mg/kg bw
Based on:
act. ingr.
Interpretation of results:
GHS criteria not met
Conclusions:
At the concentration of 4830 mg/kg bw (Swiss male mouse) the results obtained support the conclusion that AGS may be considered non-hazardous.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
4 830 mg/kg bw

Additional information

Justification for classification or non-classification