Reaction mass of 1,1,2,2,3,3,3-heptafluoro-N-(heptafluoropropyl)-N-(pentafluoroethyl)propan-1-amine and 1,1,2,2,3,3,3-heptafluoro-N-(heptafluoropropyl)-N-(trifluoromethyl)propan-1-amine and 1,1,2,2,3,3,3-heptafluoro-N,N-bis(heptafluoropropyl)propan-1-amine

Endpoint summary

Additional information

MTDID 50908 is manufactured in the EU for export.  Releases are anticipated to be primarily to the atmospheric compartment. This compound is unlikely to partition to terrestrial or aquatic compartments from the atmosphere based on partition coefficients. The experimental vapor pressure (41 mm Hg at 20 °C) and read across values for Henry’s Law constant (range: 3400 - 4020 atm∙m³/mol, at 22 °C, ca. 1030 atm∙m³/mol for minor components with higher water solubility) suggest that MTDID 50908 is expected to partition from wet or dry terrestrial surfaces into the atmosphere.  Only negligible amounts of MTDID 50908 are expected to be present in aquatic systems or soils.

The logarithm of the organic carbon normalized adsorption coefficient (log Koc) is used to describe the tendency for a substance to partition from water to soils or suspended solids. The water solubility of MTDID 50908 is slight (range for predominant constituents and impurities, <0.00516 ng/mL to 1.84 ng/mL at 23.6 °C) and the log Koc range was calculated (1) to be 4.5 - >5.4 based on experimental and read across log Kow values for predominant constituents. Based on these data MTDID 50908 is anticipated to partition from water to soils and suspended solids for a short period of time. Given the rapid partitioning to the atmosphere from soils and from water, the overall net partitioning will be to the atmosphere.

The logarithm of the octanol air partition (log Koa) coefficient is used to describe the tendency of a substance to partition from air into the lipid rich tissues of air breathing organisms. The calculated log Koa values for MTDID 50908 are <1.1, based on read across of dimensionless Henry’s Law constant and experimental and read across Kow values. This log Koa range indicates that MTDID 50908 has a low potential to partition from air to the lipid rich tissues of air-breathing organisms.

MTDID 50908 is a member of the Perfluorinated Organic Chemicals, C5-C18, category. It consists predominantly of a mixture of C7-C9 perfluorinated tertiary amines, with variety of minor impurities that are also within the category definition and are considered to be category members. All of the members of this category stem from the same manufacturing process, have similar physicochemical properties including high vapor pressure and low water solubility relative to the hydrocarbon analogs (e. g., hexanes v. perfluorohexanes), and also lack any chemically reactive groups, which forms the technical basis for the category. Members of this category are fully fluorinated, meaning that fluorine, rather than hydrogen, is bonded to all carbon atoms in the molecule. Fluorine is the most electronegative of the elements (fluorine has an electronegativity of 3.98 on the Pauling scale, as compared to 2.55 for carbon or 2.20 for hydrogen). This electronegativity is expected to dominate over all other aspects of substance chemistry and is the underlying basis for similarity of substances in this category. Because these substances exhibit similarity in their physicochemical properties and toxicological properties in mammals, and because available data indicates that parent molecules are not reactive toward biological molecules and cannot undergo bioactivation or indeed any reaction by normal enzymatic processes, they are considered to constitute a chemical category. Data gaps for transport and distribution can therefore be addressed by read-across between category members. Please see IUCLID section 13 for the category justification and a matrix of physicochemical and distribution data for members of the Perfluorinated Organic Chemicals C5-C18 category.

(1) European Chemicals Bureau: Technical Guidance Document of Risk Assessment, Chapter 4.