Pidolic acid

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

The experimental work associated with this study was carried out between 11 November 2016 and 22 March 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Specific details on test material used for the study:

Test substances: (2S)-5-oxopyrrolidine-2-carboxylic acid Technical Materials
Acid Source: (2S)-5-oxopyrrolidine-2-carboxylic acid (Acid Source)
Salt Source: (2S)-5-oxopyrrolidine-2-carboxylic acid (Potassium Salt)
Received on: 8th November 2016
DNAL Sample Numbers: DNA3730/1-2
Reference Standard: (S)-(-)-2-Pyrrolidinone-5-carboxylic acid reference standard
Received on: 6th January 2017

Key result

Test no.:

#1

Temp.:

ca. 25 °C

Vapour pressure:

< 2 other: mPa

Remarks on result:

other: using 360L of gas flow through the column

Key result

Test no.:

#2

Temp.:

ca. 25 °C

Vapour pressure:

< 8 other: mPa

Remarks on result:

other: using 72L of gas flow through the column.

Vapour Pressure (72L of gas through the column) Results Reference Standard

Description	Data File	Retention time (mins)	Unit Area	Response Factor	Concentration (mg/mL)	Weight in (g) on sorbant tube	Vapour pressure (Pa)	Vapour pressure (mPa)
0.05mg/mL L-PCA	L1603S9	5.18	414.04	0.000121
L-PCA Ref Standard/A VP Front 1 Day	LL603V1	ND	ND		<0.002	0.00003	<0.008	<0.8
L-PCA Ref Standard/B VP Front 1 Day	LL603V2	ND	ND		<0.002	0.00003	<0.008	<8.0
0.05mg/mL L-PCA	L1603S10	5.19	411.35	0.000122		Mean	<0.008	<8.0
L-PCA Ref Standard/A VP Back 1 Day	LL603V3	ND	ND		<0.002	0.00003	<0.008	<8.0
L-PCA Ref Standard/B VP Back 1 Day	LL603V4	ND	ND		<0.002	0.00003	<0.008	<8.0
0.05mg/mL L-PCA	L1603S11	5.20	409.02			Mean:	<0.008	<8.0

Vapour pressure (360L o f gas through the column) Results Reference Standard

Description	Data File	Retention time (mins)	Unit Area	Response Factor	Concentration (mg/mL)	Weight in (g) on sorbant tube	Vapour pressure (Pa)	Vapour pressure (mPa)
0.05mg/mL L-PCA	L1603S11	5.20	409.02	0.000121
L-PCA Ref Standard/A VP Front 5 Day	LL603V5	ND	ND		<0.002	0.00003	<0.002	<2.0
L-PCA Ref Standard/B VP Front 5 Day	LL603V6	ND	ND		<0.002	0.00003	<0.002	<2.0
0.05mg/mL L-PCA	L1603S12	5.21	417.38	0.000118		Mean	<0.002	<2.0
L-PCA Ref Standard/A VP Back 5 Day	LL603V7	ND	ND		<0.002	0.00003	<0.002	<2.0
L-PCA Ref Standard/B VP Back 5 Day	LL603V8	ND	ND		<0.002	0.00003	<0.002	<2.0
0.05mg/mL L-PCA	L1603S13	5.21	428.79			Mean:	<0.002	<2.0

Where:

Response Factor= 0.05/mean standard bracket area

Concentration (mg/mL) =Less than Lowest standard concentration (LOQ)

Molecular Weight= 129.12

Temperature (K) = 298

Gas Constant= 8.314

Volume (m3) =((Time (in hours) x 60 x 50)/1000)/1000

Grams on tube = Concentration x 15/ 1000

Vapour Pressure Pa= (grams on tube /volume) x ((8.314 x 298)/129.12)

Vapour Pressure mPa = Vapour Pressure Pa x 1000

No significant deviation was recorded in this part of the study.

Conclusions:

According to the results obtained in this test, the mean Vapour Pressure of (2S)-5-oxopyrrolidine-2-carboxylic acid is <2.0mPa at 25°C using 360L of gas flow through the column.
According to the results obtained in this test, the mean Vapour Pressure of (2S)-5-oxopyrrolidine-2-carboxylic acid is <8.0mPa at 25°C using 72L of gas flow through the column.

Description of key information

The mean Vapour Pressure of (2S)-5-oxopyrrolidine-2-carboxylic acid is <2.0mPa at 25°C using 360L of gas flow through the column and <8.0mPa at 25°C using 72L of gas flow through the column.

Key value for chemical safety assessment

Vapour pressure:

0.002 Pa

at the temperature of:

25 °C