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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From September 18, 2017 to December 05, 2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
equivalent or similar to
Guideline:
other: ISO 2591-1
Version / remarks:
ISO 2591-1:1988, Test sieving -- Part 1: Methods using test sieves of woven wire cloth and perforated metal plate
Deviations:
not specified
Principles of method if other than guideline:
To characterise the particle size distribution of the test substance, the analysis was conducted initially using an optical microscope analysis and was then undertaken more formally using a manual sieve analysis.
GLP compliance:
yes
Type of method:
other: Sieving and microscopic examination
Type of particle tested:
other: As received, the test substance is observed to be white pellets
Type of distribution:
mass based distribution
No.:
#1
Size:
> 2 000 µm
Distribution:
ca. 99.95 %
No.:
#2
Size:
< 2 000 µm
Distribution:
ca. 0.05 %
Remarks on result:
other: The test substance was found to be a solid block with few broken bits. Due to the small amount of material < 2000 µm present in the test substance it was not possible to carry out particle size distribution by laser diffraction.

Results 

1) Optical microscope analysis

Standard visual observation

Sample observed to be large solid free flowing lumps that are up to 40 mm in length.

 

Observation using 3.2 objective lens

Particles < 2000 µm were used. The particles appeared to be irregular amorphous particles.

2) Manual sieve analysis

Full test results

Sieve size (µm)

Sieve weight (g)

Sieve + powder weight (g)

Powder weight (g)

% by weight

< 2000

356.2

356.3

0.1

0.05

> 2000

325.7

525.6

199.9

99.95

TOTALS

200.0

100.0

The test substance was found to be a solid block with few broken bits. Due to the small amount of material < 2000 µm present in the test substance it was not possible to carry out particle size distribution by laser diffraction.

Conclusions:
Under the study conditions, the particle size for >99.95% by weight of the test substance was considered to be >2000 µm .
Executive summary:

A study was conducted to determine the particle size distribution of the test substance (Purity: 100%), by optical microscopic and manual sieve analysis. Under the study conditions, the particle size for >99.95% by weight of the test substance was determined to be >2000 µm (Chilworth, 2017).

Description of key information

The particle size distribution of the test substance was determined by optical microscopic and manual sieve analysis method (Chilworth, 2017).

Additional information

Value used for CSA: >99.95% by weight of the test substance were determined to >2000 µm.