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EC number: 305-928-2 | CAS number: 95370-65-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 August 2017 to 17 November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 65 600 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- 3 d
- Temp.:
- 20 °C
- pH:
- 5
- Remarks on result:
- other: 65.6 ± 1.43 mg/mL
- Details on results:
- - pH of the samples varied in the range of 4.94 – 5.00.
- The concentration in the clear solvent phase of samples were analysed with the HPLC method. Measured concentrations are summarised in Table 2.
- From the highest visually acceptable solution, the concentration was determined to be 65.6 ± 1.43 mg/mL (95 % confidence interval) at 20 ± 0.5 °C using the shake-flask method. - Conclusions:
- Under the conditions of this study, the water solubility of the test material was determined to be 65.6 ± 1.43 mg/mL (95 % confidence interval) at 20 ± 0.5 °C.
- Executive summary:
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105 and EU Method A.6, under GLP conditions.
The test material: water ratio used for the main test was determined in a preliminary visual assessment. About 1.75 g of test material was measured into stoppered Erlenmeyer flasks (three parallel). After the addition of 25 mL ultrapure water, the flasks were agitated at 30 °C. After one and two days, three other similarly prepared flasks were agitated at 30 °C. One day later all of the vessels were removed and re-equilibrated at 20 °C for 24 hours. The samples were filtered, then diluted before the analysis (two parallel dilutions and two injections each). The concentration of the samples was determined by HPLC.
Under the conditions of this study, the water solubility of the test material was determined to be 65.6 ± 1.43 mg/mL (95 % confidence interval) at 20 ± 0.5 °C.
Reference
Table 1: Preliminary test of the different ratio of mixtures by visual assessment
How many times excess of the estim. solubility |
Amount of |
Visual Observations |
|||
Test Material (g) |
Water (mL) |
Shaking |
Re-equilibration |
For further analysis |
|
at 30 °C |
at 20 °C |
||||
1x |
1.75 |
25 |
apparently a colourless solution |
slight crystallisation |
filterable, solution-like |
2x |
3.50 |
25 |
apparently a white, viscous suspension |
cream-like suspension |
untreatable |
3x |
5.25 |
25 |
apparently a white, viscous suspension |
cream-like suspension |
untreatable |
4x |
7.00 |
25 |
apparently a white, viscous suspension |
cream-like suspension |
untreatable |
Table 2: Results of the determination of the test material concentrations
Measured concentration after 1 day (mg/mL) |
pH |
Measured concentration after 2 days (mg/mL) |
pH |
Measured concentration after 3 days (mg/mL) |
pH |
Concentration of the test material* (mg/mL) |
64.9 |
5.00 |
62.5 |
4.96 |
64.8 |
5.00 |
65.6 ± 1.43 |
64.6 |
4.98 |
65.1 |
4.96 |
65.5 |
4.94 |
|
68.1 |
4.96 |
66.3 |
4.95 |
68.5 |
4.96 |
|
Mean: 65.9 |
- |
Mean: 64.6 |
- |
Mean: 66.3 |
- |
RSD% = 2.8 % |
* From a solution made at the maximum visual concentration as a solution, at 1.75 g test material per 25 mL.
Description of key information
Under the conditions of this study, the water solubility of the test material was determined to be 65.6 ± 1.43 mg/mL (95 % confidence interval) at 20 ± 0.5 °C.
Key value for chemical safety assessment
- Water solubility:
- 65 600 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material was investigated in accordance with the standardised guidelines OECD 105 and EU Method A.6, under GLP conditions. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
The test material: water ratio used for the main test was determined in a preliminary visual assessment. About 1.75 g of test material was measured into stoppered Erlenmeyer flasks (three parallel). After the addition of 25 mL ultrapure water, the flasks were agitated at 30 °C. After one and two days, three other similarly prepared flasks were agitated at 30 °C. One day later all of the vessels were removed and re-equilibrated at 20 °C for 24 hours. The samples were filtered, then diluted before the analysis (two parallel dilutions and two injections each). The concentration of the samples was determined by HPLC.
Under the conditions of this study, the water solubility of the test material was determined to be 65.6 ± 1.43 mg/mL (95 % confidence interval) at 20 ± 0.5 °C.
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