Registration Dossier

Physical & Chemical properties

Melting point / freezing point

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
31 January 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
2008
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
capillary method
Specific details on test material used for the study:
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
-Storage conditions: Room temperature.
Key result
Melting / freezing pt.:
184.2 °C
Remarks on result:
other: At about 183 °C slight bubble-formation could be seen and the test item began to turn brown, suggesting degradation at approximately the same temperature as the melting point.

Using a linear heating rate of 0.5 °C/min, the melting point of the test material was found to be 184.2 ± 0.08 °C (95 % confidence interval), i.e. 457.3 K, but at about 183 °C slight bubble-formation could be seen and the test material began to turn brown.

Measured temperatures corresponding to the melting of the test material (three experiments (I, II, III) with three parallel samples each (1, 2, 3))

Melting Point

Measured temperatures during the main study (°C)

I/1

I/2

I/3

II/1

II/2

II/3

III/1

III/2

III/3

Mean

184.0

184.1

184.2

184.2

184.3

184.1

184.2

184.3

184.3

184.2 ± 0.08

Conclusions:
Under the conditions of this study, the melting point of the test material was found to be 184.2 ± 0.08 °C, with slight bubble-formation and colouration suggesting degradation at approximately the same temperature as the melting point.
Executive summary:

The melting point of the test material was determined in accordance with the standardised guidelines OECD 102 and EU Method A.1 under GLP conditions using the capillary method.

A small amount of the test material was heated in the electronic controlled sample block and the temperature around the sample was displayed. The sample was observed visually whilst raising the temperature. The initial and final melting temperatures were determined.

Using a linear heating rate of 0.5 °C/min the melting point of the test material was found to be 184.2 ± 0.08 °C (95 % confidence interval), i.e. 457.3 K with slight bubble-formation and colouration suggesting degradation at approximately the same temperature as the melting point.

Under the conditions of this study, the melting point of the test material was found to be 184.2 ± 0.08 °C.

Description of key information

Under the conditions of this study, the melting point of the test material was found to be 184.2 ± 0.08 °C with slight bubble-formation and colouration suggesting degradation at approximately the same temperature as the melting point.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
184.2 °C

Additional information

The melting point of the test material was determined in accordance with the standardised guidelines OECD 102 and EU Method A.1 under GLP conditions using the capillary method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

A small amount of the test material was heated in the electronic controlled sample block and the temperature around the sample was displayed. The sample was observed visually whilst raising the temperature. The initial and final melting temperatures were determined.

Using a linear heating rate of 0.5 °C/min the melting point of the test material was found to be 184.2 ± 0.08 °C (95 % confidence interval), i.e. 457.3 K with slight bubble-formation and colouration suggesting degradation at approximately the same temperature as the melting point.

Under the conditions of this study, the melting point of the test material was found to be 184.2 ± 0.08 °C.