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Ecotoxicological information

Toxicity to microorganisms

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Description of key information

Not toxic to microorganisms; toxicity control of ready biodegradability conducted according to OECD 301B

Key value for chemical safety assessment

Additional information

The toxicity control of the available study on ready biodegradability conducted according to OECD 301B is used to derive a NOEC for the toxicity to aquatic microorganisms. If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2017). A substance can be assumed to be not inhibitory to aquatic microorganisms, if in the toxicity control of a ready biodegradation test, more than 25% degradation based on oxygen demand (BOD/ThOD) occurred within 14 days (OECD guideline 301). For Nonanoic acid, esters with adipic acid and trimethylolpropane a biodegradation test according to OECD guideline 301B is available. The test includes a toxicity control, which contains 53.08 mg/L of the test item and 121.4 mg/L of the reference material, sodium benzoate. The toxicity control attained 71 % degradation after 14 days of incubation. Hence, the substance is not toxic to aquatic microorganisms in the toxicity control and the test item concentration of 53.08 mg/L can be used as NOEC (NOEC (14 d) ≥ 53.08 mg/L).