Registration Dossier
Registration Dossier
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EC number: 211-854-0 | CAS number: 701-35-9
Endpoint summary
Administrative data
Description of key information
No in vivo data are available for skin irritation/corrosion or eye irritation of trichloro-p-tolylsilane.
However, based on the fact that this substance is a chlorosilane, so generates hydrogen chloride in the presence of moisture, it is expected to be corrosive. Therefore, in accordance with Column 2 of REACH Annex VIII, the in vivo skin irritation study and eye irritation study (required in Section 8.1.1 and 8.2.1) do not need to be conducted as the available information indicates that the substance meets the criteria for classification as corrosive to skin.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Trichloro(4 -methylphenyl)silane hydrolyses very rapidly (half-life <1 min at pH 7) in contact with water and moist air, releasing three moles of hydrogen chloride (HCl) for each mole of parent material. Although no in vivo irritation/corrosion studies are available, severe skin, eye and respiratory damage can be expected due to release of HCl. This is consistent with reliable measured data for other chlorosilanes.
Justification for classification or non-classification
Trichloro(4 -methylphenyl)silane is classified as Skin Corrosive Category 1A with the hazard statement H314 ‘Causes severe skin burns and eye damage’ according to Regulation (EC) 1272/2008.
There are no experimental data for respiratory tract irritation. The additional hazard statement EUH071 ‘Corrosive to the respiratory tract' (Regulation (EC) 1272/2008) is proposed in accordance with anticipated respiratory tract damage due to the hydrolysis product HCl generated by chlorosilanes on contact with moisture.
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