sec-butylamine

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

GLP compliance:

no

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

sec-butylamine

EC Number:

237-732-7

EC Name:

sec-butylamine

Cas Number:

13952-84-6

Molecular formula:

C4H11N

IUPAC Name:

butan-2-amine

Test animals

Species:

mouse

Strain:

other: WBS/S

Details on test animals or test system and environmental conditions:

5 MALES OF wbs/s MICE 527+/- g BW) were placed in each of a series of 20-liter exposure chambers and the latter sealed airtight. A measured volume of the sample was then injected upon a disc of filter paper suspended in each chamber. (The sample was seen to evaporate completely within 20 seconds). The mice were observed continuously during an exposure period of one hour and suviving animals were observed for 11 days.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

not specified

Details on inhalation exposure:

5 MALES OF wbs/s MICE 527+/- g BW) were placed in each of a series of 20-litter exposure chambers and the latter sealed airtight. A measured volume of the sample was then injected upon a disc of filter paper suspended in each chamber. (The sample was seen to evaporate completely within 20 seconds). The mice were observed continuously during an exposure period of one hour and suviving animals were observed for 11 days.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

1 h

Concentrations:

8, 10, 12.5, 16, 20 and 25 mg/l

No. of animals per sex per dose:

5 males

Control animals:

no

Details on study design:

5 MALES OF wbs/s MICE 527+/- g BW) were placed in each of a series of 20-litter exposure chambers and the latter sealed airtight. A measured volume of the sample was then injected upon a disc of filter paper suspended in each chamber. (The sample was seen to evaporate completely within 20 seconds). The mice were observed continuously during an exposure period of one hour and suviving animals were observed for 11 days.

Statistics:

none

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LC50

Effect level:

11.2 mg/L air

Based on:

test mat.

Exp. duration:

1 h

Mortality:

0 % mortality at 8 mg/L
20% mortality at 10 mg/l
80% mortality at 12.5 mg/L
100% mortality at 16 mg/L
100% mortality at 20 mg/l
100% mortality at 25 mg/l

Clinical signs:

other: severe sensory irritation, dffrantic escape activity, salivation and bronchospastic gasping.

Body weight:

not recorded

Gross pathology:

not examined

Applicant's summary and conclusion

Interpretation of results:

Category 3 based on GHS criteria

Executive summary:

5 males of wbs/s MICE 527+/- g BW were placed in each of a series of 20-litter exposure chambers and the latter sealed airtight. A measured volume of the sample was then injected upon a disc of filter paper suspended in each chamber. (The sample was seen to evaporate completely within 20 seconds). The mice were observed continuously during an exposure period of one hour and suviving animals were observed for 11 days. The LC 50 was set at 11.2 mg/l (3680 ppm).