Registration Dossier

Environmental fate & pathways

Hydrolysis

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Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1999
Report Date:
1999

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
yes
Remarks:
source of test material not stated; information on test conditions not reported
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
- Appearance: light yellow crystalline powder
- Melting point: 111.3 °C
- Boiling point: 263 °C
- Molecular weight: 136.15 g/mol
Radiolabelling:
not specified

Study design

Analytical monitoring:
not specified
Buffers:
Buffer not specified in report.
Details on test conditions:
TEST SYSTEM
- Type, material and volume of test flasks: glass test tube with stopper
- Sterilisation method: not reported
- Lighting: not reported

TEST MEDIUM
- No information on test medium reported
Duration of testopen allclose all
Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
100 mg/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
100 mg/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
100 mg/L
Number of replicates:
2
Positive controls:
not specified
Negative controls:
not specified

Results and discussion

Preliminary study:
As a result of the preliminary test, it was judged that the test substance was not hydrolyzable at pH 4, 7 and 9.
Transformation products:
not specified
Details on results:
As a result of the preliminary test, it was judged that the test substance was not hydrolyzable at pH 4, 7 and 9.

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
Only limited information on test conditions and results is provided. Although the study was performed according to OECD guideline 111, it is not possible to confirm full guideline compliance. It remains unclear from which analytical results it was concluded that m-toluic acid is not hydrolyzable and that further testing is not required. Thus, this study is considered supporting data.