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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From March 18, 1989 to July 26, 1989
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method

Test material

Constituent 1
Test material form:
solid

Results and discussion

Water solubility
Key result
Water solubility:
> 200 g/L
Conc. based on:
test mat.
Incubation duration:
ca. 4 - ca. 8 d
Temp.:
22 °C
pH:
ca. 6.3 - ca. 6.34

Any other information on results incl. tables

No evidence of chemical instability was observed.

All three tests were completely in solution with no visible solid being detected.

Results:

Test   Test 1  Test 2  Test 3
Duration 4 days 7 days 8 days
Weight of Test Substance (g) 8.6669 8.3417 8.088
Weight of Distilled Water (g) 19.4184 21.2361 19.984
Test Dilution with Distilled Water
0.0527 g to 100 mL
Then
0.0922 g to 100 mL
Then
0.0625 g to 100 mL
Then
(1)
5.0 mL to 100 mL
(2)
25.0 mL to 100 mL
(1)
25.0 mL to 100 mL
(2)
10.0 mL to 100 mL
(1)
25.0 mL to 100 mL
(2)
10.0 mL to 100 mL
Absorbance (1 cm cell, 415 nm) 0.233 1.141 1.818 0.733 1.248 0.499
Pg/mL 7.75 39 62 25 42.5 17.25
% w/w Solubility 29.4 29.6 26.9 27.1 27.2 27.6
% w/w Solubility (adjusted for 10.7 % H2O content)
26.3 26.4 24 24.2 24.3 24.7
pH  6.34 6.3 not tested

Applicant's summary and conclusion

Conclusions:
Under the study conditions, the water solubility of the substance was determined to be > 200 g/L at 22°C.
Executive summary:

A study was conducted to determine the water solubility of the substance according to EU Method A.6, using flask method. Under the study conditions, the water solubility of the substance was determined to be > 200000 mg/L at 22°C (Williams, 1989).