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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-04-21 to 2017-04-26
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
yes
Remarks:
With respect to the test design, no phase separation via centrifugation is necessary.
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
Council Regulation (EC) No. 260/2014, Method A.6 modified according to Letinski et al. (2002) and OECD 123 (2006)
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Key result
Water solubility:
4.37 mg/L
Conc. based on:
test mat.
Incubation duration:
72 h
Temp.:
20 °C
pH:
5.6
Conclusions:
The water solubility of the test item was determined to be 4.37 mg/L at 20°C pH 5.6.
Executive summary:

The water solubility of the test item was determined according to GLP, OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6, modified according to Letinski et al. (2002) and OECD 123 (2006). The solubility of the test item in double distilled water was determined employing the flask method with slow stirring approach at 20 ± 0.5 °C with incubation at test temperature for 72 h before the first sampling.

The analytical method (GC-MS, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.

The water solubility of the test item was determined to be 4.37 mg/L at 20°C pH 5.6.

Description of key information

The water solubility of the test item was determined to be 4.37 mg/L at 20°C pH 5.6.

Key value for chemical safety assessment

Water solubility:
4.37 mg/L
at the temperature of:
20 °C

Additional information

The water solubility of the test item was determined according to GLP, OECD guideline 105 (1995) and Council Regulation (EC) No. 260/2014, Method A.6, modified according to Letinski et al. (2002) and OECD 123 (2006). The solubility of the test item in double distilled water was determined employing the flask method with slow stirring approach at 20 ± 0.5 °C with incubation at test temperature for 72 h before the first sampling.

The analytical method (GC-MS, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.

The water solubility of the test item was determined to be 4.37 mg/L at 20°C pH 5.6.