Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
Toxicology and Applied Pharmacology. Vol. 63, Pg. 150
Year:
1982
Bibliographic source:
Toxicology and Applied Pharmacology. Vol. 63

Materials and methods

Principles of method if other than guideline:
Not available
GLP compliance:
not specified

Test material

1
Chemical structure
Reference substance name:
sec-butylamine
EC Number:
237-732-7
EC Name:
sec-butylamine
Cas Number:
13952-84-6
Molecular formula:
C4H11N
IUPAC Name:
butan-2-amine
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
152 mg/kg bw
Clinical signs:
other: LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA BEHAVIORAL: ANTIPSYCHOTIC

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria