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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
(3β,20β)-3-acetoxy-11-oxoolean-12-en-29-oic acid
EC Number:
228-475-1
EC Name:
(3β,20β)-3-acetoxy-11-oxoolean-12-en-29-oic acid
Cas Number:
6277-14-1
Molecular formula:
C32H48O5
IUPAC Name:
(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-acetyloxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
ca. 4.77
Temp.:
35 °C
pH:
ca. 2.25
Remarks on result:
other: Mean of 3 results.

Any other information on results incl. tables

 Elution condiction  Log K  Log K ow
 20:80  3.1014 0.4916   4.77
 (water: MeOH) 3.1014   0.4916  4.77
at 35°C and pH=2.25  3.1074   0.4924  4.77
      Mean= 4.77 (RSD% 0.03) 

Applicant's summary and conclusion

Conclusions:
The Log Pow of Acetyl Glycyrrhetinic Acid is: 4.77.